ReviewBMC nephrology2016
Low protein diets in patients with chronic kidney disease: a bridge between mainstream and complementary-alternative medicines?
Review in BMC nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Nutritional status improvement in elderly CKD patients: a systematic review.International urology and nephrology · 2021Pooled it
- Low protein diets for non-diabetic adults with chronic kidney disease.The Cochrane database of systematic reviews · 2020Pooled it
- Low protein diets for non-diabetic adults with chronic kidney disease.The Cochrane database of systematic reviews · 2018Pooled it
- Effect of essential amino acid кetoanalogues and protein restriction diet on morphogenetic proteins (FGF-23 and Кlotho) in 3b-4 stages chronic кidney disease patients: a randomized pilot study.Clinical and experimental nephrology · 2018Trial
- Epidemiological research on diabetic nephropathy at global, regional, and national levels from 1990 to 2021: an analysis derived from the global burden of disease 2021 study.Frontiers in endocrinology · 2025Article
- Personalized Medicine in Kidney Disease.Journal of personalized medicine · 2023Article
- Predialysis Urea Nitrogen Is a Nutritional Marker of Hemodialysis Patients.Chonnam medical journal · 2022Article
- Supplemented Low-Protein Diet May Delay the Need for Preemptive Kidney Transplantation: A Nationwide Population-Based Cohort Study.Nutrients · 2021Article
- Quality of Life in CKD Patients on Low-Protein Diets in a Multiple-Choice Diet System. Comparison between a French and an Italian Experience.Nutrients · 2021Observational
- Ketoanalogs' Effects on Intestinal Microbiota Modulation and Uremic Toxins Serum Levels in Chronic Kidney Disease (Medika2 Study).Journal of clinical medicine · 2021Article
- Plant-based diets to manage the risks and complications of chronic kidney disease.Nature reviews. Nephrology · 2020Review
- Green nephrology and eco-dialysis: a position statement by the Italian Society of Nephrology.Journal of nephrology · 2020Article
- Green nephrology.Nature reviews. Nephrology · 2020Review
- Nutritional Therapy Modulates Intestinal Microbiota and Reduces Serum Levels of Total and Free Indoxyl Sulfate and P-Cresyl Sulfate in Chronic Kidney Disease (Medika Study).Journal of clinical medicine · 2019Article
- Review
- Microbiota issue in CKD: how promising are gut-targeted approaches?Journal of nephrology · 2019Review
- The strange case of Mr. H. Starting dialysis at 90 years of age: clinical choices impact on ethical decisions.BMC medical ethics · 2017Article
- Chronic kidney disease progression: a retrospective analysis of 3-year adherence to a low protein diet.Renal failure · 2017Article
- Dietary Phosphorus Intake and the Kidney.Annual review of nutrition · 2017Review
- The systemic nature of CKD.Nature reviews. Nephrology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dietary therapy represents an important tool in the management of chronic kidney disease (CKD), mainly through a balanced reduction of protein intake aimed at giving the remnant nephrons in damaged kidneys a "functional rest". While dialysis, transplantation, and pharmacological therapies are usually seen as "high tech" medicine, non pharmacological interventions, including diets, are frequently considered lifestyle-complementary treatments. Diet is one of the oldest CKD treatments, and it is usually considered a part of "mainstream" management. In this narrative review we discuss how the lessons of complementary alternative medicines (CAMs) can be useful for the implementation and study of low-protein diets in CKD. While high tech medicine is mainly prescriptive, prescribing a "good" life-style change is usually not enough and comprehensive counselling is required; the empathic educational approach, on which CAMs are mainly, though not exclusively based, may support a successful personalized nutritional intervention.There is no gold-standard, low-protein diet for all CKD patients: from among a relatively vast choice, the best compliance is probably obtained by personalization. This approach interferes with the traditional RCT-based analyses which are grounded upon an assumption of equal preference of treatments (ideally blinded). Whole system approaches and narrative medicine, that are widely used in the study of CAMs, may offer ways to integrate EBM and personalised medicine in the search for innovative solutions respecting individualization, but gaining sound data, such as with partially-randomised patient preference trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.