ArticleMicrobiome2016
Longitudinal analysis of the lung microbiota of cynomolgous macaques during long-term SHIV infection.
Article in Microbiome, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 56 citations in OpenAlex.
- Dynamic balance of the lung microbiome in health and respiratory diseases.Chinese medical journal · 2026Review
- Longitudinal change of lung microbiome in chronic obstructive pulmonary disease: a prospective cohort study.Respiratory research · 2026Article
- The lung microbiome in patients with HIV complicated with community-acquired pneumonia: a cross-sectional pilot study.Current research in microbial sciences · 2025Article
- Wise Roles and Future Visionary Endeavors of Current Emperor: Advancing Dynamic Methods for Longitudinal Microbiome Meta-Omics Data in Personalized and Precision Medicine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Helicobacter pylori infection in infant rhesus macaque monkeys is associated with an altered lung and oral microbiome.Scientific reports · 2024Article
- Exploring the lung microbiome's role in disease.Nature · 2024Article
- What Makes the Gut-Lung Axis Working? From the Perspective of Microbiota and Traditional Chinese Medicine.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2024Review
- HIV-associated lung disease.Nature reviews. Disease primers · 2023Review
- Microbiota and mycobiota in bronchoalveolar lavage fluid of silicosis patients.Journal of occupational medicine and toxicology (London, England) · 2023Article
- The dynamic lung microbiome in health and disease.Nature reviews. Microbiology · 2023Review
- Identification of Gut Microbiota Affecting Fiber Digestibility in Pigs.Current issues in molecular biology · 2022Article
- Functional, transcriptional, and microbial shifts associated with healthy pulmonary aging in rhesus macaques.Cell reports · 2022Article
- Functional response regression model on correlated longitudinal microbiome sequencing data.Statistical methods in medical research · 2022Article
- The composition of the lung microbiome differs between patients with dermatomyositis and rheumatoid arthritis associated with interstitial lung disease.FEBS open bio · 2022Article
- Microbiome Studies in Non-human Primates.Current HIV/AIDS reports · 2021Review
- Shifts in microbial diversity, composition, and functionality in the gut and genital microbiome during a natural SIV infection in vervet monkeys.Microbiome · 2020Article
- Methods in Lung Microbiome Research.American journal of respiratory cell and molecular biology · 2020Review
- Article
- Obstructive Lung Disease in HIV-Phenotypes and Pathogenesis.Current HIV/AIDS reports · 2019Review
- Utilizing longitudinal microbiome taxonomic profiles to predict food allergy via Long Short-Term Memory networks.PLoS computational biology · 2019Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundLongitudinal studies of the lung microbiome are challenging due to the invasive nature of sample collection. In addition, studies of the lung microbiome in human disease are usually performed after disease onset, limiting the ability to determine early events in the lung. We used a non-human primate model to assess lung microbiome alterations over time in response to an HIV-like immunosuppression and determined impact of the lung microbiome on development of obstructive lung disease. Cynomolgous macaques were infected with the SIV-HIV chimeric virus SHIV89.6P. Bronchoalveolar lavage fluid samples were collected pre-infection and every 4 weeks for 53 weeks post-infection. The microbiota was characterized at each time point by 16S ribosomal RNA (rRNA) sequencing.
resultsWe observed individual variation in the composition of the lung microbiota with a proportion of the macaques having Tropheryma whipplei as the dominant organism in their lungs. Bacterial communities varied over time both within and between animals, but there did not appear to be a systematic alteration due to SHIV infection. Development of obstructive lung disease in the SHIV-infected animals was characterized by a relative increase in abundance of oral anaerobes. Network analysis further identified a difference in community composition that accompanied the development of obstructive disease with negative correlations between members of the obstructed and non-obstructed groups. This emphasizes how species shifts can impact multiple other species, potentially resulting in disease.
conclusionsThis study is the first to investigate the dynamics of the lung microbiota over time and in response to immunosuppression in a non-human primate model. The persistence of oral bacteria in the lung and their association with obstruction suggest a potential role in pathogenesis. The lung microbiome in the non-human primate is a valuable tool for examining the impact of the lung microbiome in human health and disease.
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