ArticlePloS one2016
Age-Related 1H NMR Characterization of Cerebrospinal Fluid in Newborn and Young Healthy Piglets.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
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- A Deep Look at the Vaginal Environment During Pregnancy and Puerperium.Frontiers in cellular and infection microbiology · 2022Article
- Metabolomics to Diagnose Oxidative Stress in Perinatal Asphyxia: Towards a Non-Invasive Approach.Antioxidants (Basel, Switzerland) · 2021Review
- New Insights into Vaginal Environment During Pregnancy.Frontiers in molecular biosciences · 2021Article
- Pre-Pregnancy Diet and Vaginal Environment in Caucasian Pregnant Women: An Exploratory Study.Frontiers in molecular biosciences · 2021Article
- Vaginal metabolic profiles during pregnancy: Changes between first and second trimester.PloS one · 2021Article
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- Non-invasive Assessment of Fecal Stress Biomarkers in Hunting Dogs During Exercise and at Rest.Frontiers in veterinary science · 2020Article
- Diversity of vaginal microbiome and metabolome during genital infections.Scientific reports · 2019Article
- Salivary and urinary metabolome analysis for pre-puberty-related biomarkers identification in porcine.Animal : an international journal of animal bioscience · 2019Article
- Metabolic Characterization of Supernatants Produced byFrontiers in microbiology · 2019Article
- Article
- Probiotic supplementation in trained trotter horses: effect on blood clinical pathology data and urine metabolomic assessed in field.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- A probiotic modulates the microbiome and immunity in multiple sclerosis.Annals of neurology · 2018Article
- Effect of dietary arginine to lysine ratios on productive performance, meat quality, plasma and muscle metabolomics profile in fast-growing broiler chickens.Journal of animal science and biotechnology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When it comes to neuroscience, pigs represent an important animal model due to their resemblance with humans' brains for several patterns including anatomy and developmental stages. Cerebrospinal fluid (CSF) is a relatively easy-to-collect specimen that can provide important information about neurological health and function, proving its importance as both a diagnostic and biomedical monitoring tool. Consequently, it would be of high scientific interest and value to obtain more standard physiological information regarding its composition and dynamics for both swine pathology and the refinement of experimental protocols. Recently, proton nuclear magnetic resonance (1H NMR) spectroscopy has been applied in order to analyze the metabolomic profile of this biological fluid, and results showed the technique to be highly reproducible and reliable. The aim of the present study was to investigate in both qualitative and quantitative manner the composition of Cerebrospinal Fluid harvested form healthy newborn (5 days old-P5) and young (30-P30 and 50-P50 days old) piglets using 1H NMR Spectroscopy, and to analyze any possible difference in metabolites concentration between age groups, related to age and Blood-Brain-Barrier maturation. On each of the analyzed samples, 30 molecules could be observed above their limit of quantification, accounting for 95-98% of the total area of the spectra. The concentrations of adenine, tyrosine, leucine, valine, 3-hydroxyvalerate, 3-methyl-2-oxovalerate were found to decrease between P05 and P50, while the concentrations of glutamine, creatinine, methanol, trimethylamine and myo-inositol were found to increase. The P05-P30 comparison was also significant for glutamine, creatinine, adenine, tyrosine, leucine, valine, 3-hydroxyisovalerate, 3-methyl-2-oxovalerate, while for the P30-P50 comparison we found significant differences for glutamine, myo-inositol, leucine and trimethylamine. None of these molecules showed at P30 concentrations outside the P05 -P50 range.
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