ArticleJournal of psychiatry & neuroscience : JPN2017
Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: a study in male mice.
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Article in Journal of psychiatry & neuroscience : JPN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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47 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Auditory processing in rodent models of autism: a systematic review.Journal of neurodevelopmental disorders · 2022Pooled it
- Developmentally dynamic, non-convergent transcriptomic profiles in CNV models for schizophrenia risk.Molecular psychiatry · 2026Article
- Divergent transcriptomic pathways underlie sex-biased cognitive rescue by developmental GSK3B inhibition in a mouse model of 22q11.2 deletion syndrome.Translational psychiatry · 2026Article
- Prefrontal parvalbumin neurons as a target for enhancing cognition in non-pathological and 22q11.2 microdeletion syndrome mice.Molecular psychiatry · 2026Article
- Suppressive Genetic Interactions Between Haploinsufficient Mitochondrial Genes Encoded in the 22q11.2 Microdeletion Locus Define Brain and Cardiac Phenotypes.bioRxiv : the preprint server for biology · 2026Article
- Bezafibrate improves mitochondrial function, blood-brain barrier integrity, and social deficits in models of 22q11.2 deletion syndrome.Science translational medicine · 2025Article
- Rare Copy Number Variants Reveal Critical Cell Types and Periods of Brain Development in Neurodevelopmental Disorders.Biological psychiatry global open science · 2025Article
- Auditory evoked-potential abnormalities in a mouse model of 22q11.2 Deletion Syndrome and their interactions with hearing impairment.Translational psychiatry · 2025Article
- The acoustic startle response in 22q11 deletion syndrome: from animal models to humans.Frontiers in neuroscience · 2025Review
- Altered corollary discharge signaling in the auditory cortex of a mouse model of schizophrenia predisposition.Nature communications · 2023Article
- Mechanisms of copy number variants in neuropsychiatric disorders: From genes to therapeutics.Current opinion in neurobiology · 2023Review
- Ileal Dysbiosis Is Associated with Increased Acoustic Startle in the 22q11.2 Microdeletion Mouse Model of Schizophrenia.Nutrients · 2023Article
- Increased Central Auditory Gain and Decreased Parvalbumin-Positive Cortical Interneuron Density in theBiological psychiatry global open science · 2023Article
- Effects of repeated developmental GLP-1R agonist exposure on young adult behavior and hippocampal structure in mice.Neuroscience letters · 2023Article
- Event-related potential (ERP) markers of 22q11.2 deletion syndrome and associated psychosis.Journal of neurodevelopmental disorders · 2023Review
- Effects of repeated developmental GLP-1R agonist exposure on adult behavior and hippocampal structure in mice.bioRxiv : the preprint server for biology · 2023Article
- Striatal increase of dopamine receptor 2 density in idiopathic and syndromic mouse models of autism spectrum disorder.Frontiers in psychiatry · 2023Article
- The Evolving Role of Animal Models in the Discovery and Development of Novel Treatments for Psychiatric Disorders.Advances in neurobiology · 2023Article
- Current advancements of modelling schizophrenia using patient-derived induced pluripotent stem cells.Acta neuropathologica communications · 2022Review
- Relevance of interactions between dopamine and glutamate neurotransmission in schizophrenia.Molecular psychiatry · 2022Review
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Authors and funding
19 authors at 6 institutions in 6 countries.
Michael DidriksenFrom H. Lundbeck A/S, Research DK, Valby, Denmark (Didriksen Fejgin, Birknow, Larsen, Lauridsen, Nielsen, Kallunki, Christensen, Stensbøl, Egebjerg, Nielsen); the Department of Psychology, University of Cambridge, Cambridge, UK (Nilsson); the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK (Nilsson); the Lilly Centre for Cognitive Neuroscience, Lilly Research Laboratories, Windlesham, UK (Grayton, Gastambide); the Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain (Celada, Artigas); the Centro de Investigación Biomédica en Red de Salud Mental, Spain (Santana, Artigas); the Institute of Biological Psychiatry, MHC Sct. Hans, Copenhagen Mental Health Services; and the Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen; iPSYCH - The Lundbeck Foundation's Initiative for Integrative Psychiatric Research, Roskilde, Denmark (Werge).
Kim FejginFrom H. Lundbeck A/S, Research DK, Valby, Denmark (Didriksen Fejgin, Birknow, Larsen, Lauridsen, Nielsen, Kallunki, Christensen, Stensbøl, Egebjerg, Nielsen); the Department of Psychology, University of Cambridge, Cambridge, UK (Nilsson); the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK (Nilsson); the Lilly Centre for Cognitive Neuroscience, Lilly Research Laboratories, Windlesham, UK (Grayton, Gastambide); the Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain (Celada, Artigas); the Centro de Investigación Biomédica en Red de Salud Mental, Spain (Santana, Artigas); the Institute of Biological Psychiatry, MHC Sct. Hans, Copenhagen Mental Health Services; and the Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen; iPSYCH - The Lundbeck Foundation's Initiative for Integrative Psychiatric Research, Roskilde, Denmark (Werge).
Simon R O NilssonFrom H. Lundbeck A/S, Research DK, Valby, Denmark (Didriksen Fejgin, Birknow, Larsen, Lauridsen, Nielsen, Kallunki, Christensen, Stensbøl, Egebjerg, Nielsen); the Department of Psychology, University of Cambridge, Cambridge, UK (Nilsson); the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK (Nilsson); the Lilly Centre for Cognitive Neuroscience, Lilly Research Laboratories, Windlesham, UK (Grayton, Gastambide); the Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain (Celada, Artigas); the Centro de Investigación Biomédica en Red de Salud Mental, Spain (Santana, Artigas); the Institute of Biological Psychiatry, MHC Sct. Hans, Copenhagen Mental Health Services; and the Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen; iPSYCH - The Lundbeck Foundation's Initiative for Integrative Psychiatric Research, Roskilde, Denmark (Werge).
Michelle R BirknowFrom H. Lundbeck A/S, Research DK, Valby, Denmark (Didriksen Fejgin, Birknow, Larsen, Lauridsen, Nielsen, Kallunki, Christensen, Stensbøl, Egebjerg, Nielsen); the Department of Psychology, University of Cambridge, Cambridge, UK (Nilsson); the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK (Nilsson); the Lilly Centre for Cognitive Neuroscience, Lilly Research Laboratories, Windlesham, UK (Grayton, Gastambide); the Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain (Celada, Artigas); the Centro de Investigación Biomédica en Red de Salud Mental, Spain (Santana, Artigas); the Institute of Biological Psychiatry, MHC Sct. Hans, Copenhagen Mental Health Services; and the Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen; iPSYCH - The Lundbeck Foundation's Initiative for Integrative Psychiatric Research, Roskilde, Denmark (Werge).
Hannah M GraytonFrom H. Lundbeck A/S, Research DK, Valby, Denmark (Didriksen Fejgin, Birknow, Larsen, Lauridsen, Nielsen, Kallunki, Christensen, Stensbøl, Egebjerg, Nielsen); the Department of Psychology, University of Cambridge, Cambridge, UK (Nilsson); the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK (Nilsson); the Lilly Centre for Cognitive Neuroscience, Lilly Research Laboratories, Windlesham, UK (Grayton, Gastambide); the Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain (Celada, Artigas); the Centro de Investigación Biomédica en Red de Salud Mental, Spain (Santana, Artigas); the Institute of Biological Psychiatry, MHC Sct. Hans, Copenhagen Mental Health Services; and the Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen; iPSYCH - The Lundbeck Foundation's Initiative for Integrative Psychiatric Research, Roskilde, Denmark (Werge).
Peter H LarsenFrom H. Lundbeck A/S, Research DK, Valby, Denmark (Didriksen Fejgin, Birknow, Larsen, Lauridsen, Nielsen, Kallunki, Christensen, Stensbøl, Egebjerg, Nielsen); the Department of Psychology, University of Cambridge, Cambridge, UK (Nilsson); the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK (Nilsson); the Lilly Centre for Cognitive Neuroscience, Lilly Research Laboratories, Windlesham, UK (Grayton, Gastambide); the Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain (Celada, Artigas); the Centro de Investigación Biomédica en Red de Salud Mental, Spain (Santana, Artigas); the Institute of Biological Psychiatry, MHC Sct. Hans, Copenhagen Mental Health Services; and the Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen; iPSYCH - The Lundbeck Foundation's Initiative for Integrative Psychiatric Research, Roskilde, Denmark (Werge).
Jes B LauridsenFrom H. Lundbeck A/S, Research DK, Valby, Denmark (Didriksen Fejgin, Birknow, Larsen, Lauridsen, Nielsen, Kallunki, Christensen, Stensbøl, Egebjerg, Nielsen); the Department of Psychology, University of Cambridge, Cambridge, UK (Nilsson); the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK (Nilsson); the Lilly Centre for Cognitive Neuroscience, Lilly Research Laboratories, Windlesham, UK (Grayton, Gastambide); the Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain (Celada, Artigas); the Centro de Investigación Biomédica en Red de Salud Mental, Spain (Santana, Artigas); the Institute of Biological Psychiatry, MHC Sct. Hans, Copenhagen Mental Health Services; and the Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen; iPSYCH - The Lundbeck Foundation's Initiative for Integrative Psychiatric Research, Roskilde, Denmark (Werge).
Vibeke NielsenFrom H. Lundbeck A/S, Research DK, Valby, Denmark (Didriksen Fejgin, Birknow, Larsen, Lauridsen, Nielsen, Kallunki, Christensen, Stensbøl, Egebjerg, Nielsen); the Department of Psychology, University of Cambridge, Cambridge, UK (Nilsson); the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK (Nilsson); the Lilly Centre for Cognitive Neuroscience, Lilly Research Laboratories, Windlesham, UK (Grayton, Gastambide); the Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain (Celada, Artigas); the Centro de Investigación Biomédica en Red de Salud Mental, Spain (Santana, Artigas); the Institute of Biological Psychiatry, MHC Sct. Hans, Copenhagen Mental Health Services; and the Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen; iPSYCH - The Lundbeck Foundation's Initiative for Integrative Psychiatric Research, Roskilde, Denmark (Werge).
Pau CeladaFrom H. Lundbeck A/S, Research DK, Valby, Denmark (Didriksen Fejgin, Birknow, Larsen, Lauridsen, Nielsen, Kallunki, Christensen, Stensbøl, Egebjerg, Nielsen); the Department of Psychology, University of Cambridge, Cambridge, UK (Nilsson); the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK (Nilsson); the Lilly Centre for Cognitive Neuroscience, Lilly Research Laboratories, Windlesham, UK (Grayton, Gastambide); the Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain (Celada, Artigas); the Centro de Investigación Biomédica en Red de Salud Mental, Spain (Santana, Artigas); the Institute of Biological Psychiatry, MHC Sct. Hans, Copenhagen Mental Health Services; and the Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen; iPSYCH - The Lundbeck Foundation's Initiative for Integrative Psychiatric Research, Roskilde, Denmark (Werge).
Noemi SantanaFrom H. Lundbeck A/S, Research DK, Valby, Denmark (Didriksen Fejgin, Birknow, Larsen, Lauridsen, Nielsen, Kallunki, Christensen, Stensbøl, Egebjerg, Nielsen); the Department of Psychology, University of Cambridge, Cambridge, UK (Nilsson); the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK (Nilsson); the Lilly Centre for Cognitive Neuroscience, Lilly Research Laboratories, Windlesham, UK (Grayton, Gastambide); the Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain (Celada, Artigas); the Centro de Investigación Biomédica en Red de Salud Mental, Spain (Santana, Artigas); the Institute of Biological Psychiatry, MHC Sct. Hans, Copenhagen Mental Health Services; and the Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen; iPSYCH - The Lundbeck Foundation's Initiative for Integrative Psychiatric Research, Roskilde, Denmark (Werge).
Pekka KallunkiFrom H. Lundbeck A/S, Research DK, Valby, Denmark (Didriksen Fejgin, Birknow, Larsen, Lauridsen, Nielsen, Kallunki, Christensen, Stensbøl, Egebjerg, Nielsen); the Department of Psychology, University of Cambridge, Cambridge, UK (Nilsson); the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK (Nilsson); the Lilly Centre for Cognitive Neuroscience, Lilly Research Laboratories, Windlesham, UK (Grayton, Gastambide); the Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain (Celada, Artigas); the Centro de Investigación Biomédica en Red de Salud Mental, Spain (Santana, Artigas); the Institute of Biological Psychiatry, MHC Sct. Hans, Copenhagen Mental Health Services; and the Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen; iPSYCH - The Lundbeck Foundation's Initiative for Integrative Psychiatric Research, Roskilde, Denmark (Werge).
Kenneth V ChristensenFrom H. Lundbeck A/S, Research DK, Valby, Denmark (Didriksen Fejgin, Birknow, Larsen, Lauridsen, Nielsen, Kallunki, Christensen, Stensbøl, Egebjerg, Nielsen); the Department of Psychology, University of Cambridge, Cambridge, UK (Nilsson); the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK (Nilsson); the Lilly Centre for Cognitive Neuroscience, Lilly Research Laboratories, Windlesham, UK (Grayton, Gastambide); the Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain (Celada, Artigas); the Centro de Investigación Biomédica en Red de Salud Mental, Spain (Santana, Artigas); the Institute of Biological Psychiatry, MHC Sct. Hans, Copenhagen Mental Health Services; and the Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen; iPSYCH - The Lundbeck Foundation's Initiative for Integrative Psychiatric Research, Roskilde, Denmark (Werge).
Thomas M WergeFrom H. Lundbeck A/S, Research DK, Valby, Denmark (Didriksen Fejgin, Birknow, Larsen, Lauridsen, Nielsen, Kallunki, Christensen, Stensbøl, Egebjerg, Nielsen); the Department of Psychology, University of Cambridge, Cambridge, UK (Nilsson); the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK (Nilsson); the Lilly Centre for Cognitive Neuroscience, Lilly Research Laboratories, Windlesham, UK (Grayton, Gastambide); the Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain (Celada, Artigas); the Centro de Investigación Biomédica en Red de Salud Mental, Spain (Santana, Artigas); the Institute of Biological Psychiatry, MHC Sct. Hans, Copenhagen Mental Health Services; and the Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen; iPSYCH - The Lundbeck Foundation's Initiative for Integrative Psychiatric Research, Roskilde, Denmark (Werge).
Tine B StensbølFrom H. Lundbeck A/S, Research DK, Valby, Denmark (Didriksen Fejgin, Birknow, Larsen, Lauridsen, Nielsen, Kallunki, Christensen, Stensbøl, Egebjerg, Nielsen); the Department of Psychology, University of Cambridge, Cambridge, UK (Nilsson); the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK (Nilsson); the Lilly Centre for Cognitive Neuroscience, Lilly Research Laboratories, Windlesham, UK (Grayton, Gastambide); the Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain (Celada, Artigas); the Centro de Investigación Biomédica en Red de Salud Mental, Spain (Santana, Artigas); the Institute of Biological Psychiatry, MHC Sct. Hans, Copenhagen Mental Health Services; and the Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen; iPSYCH - The Lundbeck Foundation's Initiative for Integrative Psychiatric Research, Roskilde, Denmark (Werge).
Jan EgebjergFrom H. Lundbeck A/S, Research DK, Valby, Denmark (Didriksen Fejgin, Birknow, Larsen, Lauridsen, Nielsen, Kallunki, Christensen, Stensbøl, Egebjerg, Nielsen); the Department of Psychology, University of Cambridge, Cambridge, UK (Nilsson); the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK (Nilsson); the Lilly Centre for Cognitive Neuroscience, Lilly Research Laboratories, Windlesham, UK (Grayton, Gastambide); the Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain (Celada, Artigas); the Centro de Investigación Biomédica en Red de Salud Mental, Spain (Santana, Artigas); the Institute of Biological Psychiatry, MHC Sct. Hans, Copenhagen Mental Health Services; and the Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen; iPSYCH - The Lundbeck Foundation's Initiative for Integrative Psychiatric Research, Roskilde, Denmark (Werge).
Francois GastambideFrom H. Lundbeck A/S, Research DK, Valby, Denmark (Didriksen Fejgin, Birknow, Larsen, Lauridsen, Nielsen, Kallunki, Christensen, Stensbøl, Egebjerg, Nielsen); the Department of Psychology, University of Cambridge, Cambridge, UK (Nilsson); the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK (Nilsson); the Lilly Centre for Cognitive Neuroscience, Lilly Research Laboratories, Windlesham, UK (Grayton, Gastambide); the Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain (Celada, Artigas); the Centro de Investigación Biomédica en Red de Salud Mental, Spain (Santana, Artigas); the Institute of Biological Psychiatry, MHC Sct. Hans, Copenhagen Mental Health Services; and the Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen; iPSYCH - The Lundbeck Foundation's Initiative for Integrative Psychiatric Research, Roskilde, Denmark (Werge).
Francesc ArtigasFrom H. Lundbeck A/S, Research DK, Valby, Denmark (Didriksen Fejgin, Birknow, Larsen, Lauridsen, Nielsen, Kallunki, Christensen, Stensbøl, Egebjerg, Nielsen); the Department of Psychology, University of Cambridge, Cambridge, UK (Nilsson); the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK (Nilsson); the Lilly Centre for Cognitive Neuroscience, Lilly Research Laboratories, Windlesham, UK (Grayton, Gastambide); the Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain (Celada, Artigas); the Centro de Investigación Biomédica en Red de Salud Mental, Spain (Santana, Artigas); the Institute of Biological Psychiatry, MHC Sct. Hans, Copenhagen Mental Health Services; and the Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen; iPSYCH - The Lundbeck Foundation's Initiative for Integrative Psychiatric Research, Roskilde, Denmark (Werge).
Jesper F BastlundFrom H. Lundbeck A/S, Research DK, Valby, Denmark (Didriksen Fejgin, Birknow, Larsen, Lauridsen, Nielsen, Kallunki, Christensen, Stensbøl, Egebjerg, Nielsen); the Department of Psychology, University of Cambridge, Cambridge, UK (Nilsson); the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK (Nilsson); the Lilly Centre for Cognitive Neuroscience, Lilly Research Laboratories, Windlesham, UK (Grayton, Gastambide); the Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain (Celada, Artigas); the Centro de Investigación Biomédica en Red de Salud Mental, Spain (Santana, Artigas); the Institute of Biological Psychiatry, MHC Sct. Hans, Copenhagen Mental Health Services; and the Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen; iPSYCH - The Lundbeck Foundation's Initiative for Integrative Psychiatric Research, Roskilde, Denmark (Werge).
Jacob NielsenFrom H. Lundbeck A/S, Research DK, Valby, Denmark (Didriksen Fejgin, Birknow, Larsen, Lauridsen, Nielsen, Kallunki, Christensen, Stensbøl, Egebjerg, Nielsen); the Department of Psychology, University of Cambridge, Cambridge, UK (Nilsson); the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK (Nilsson); the Lilly Centre for Cognitive Neuroscience, Lilly Research Laboratories, Windlesham, UK (Grayton, Gastambide); the Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain (Celada, Artigas); the Centro de Investigación Biomédica en Red de Salud Mental, Spain (Santana, Artigas); the Institute of Biological Psychiatry, MHC Sct. Hans, Copenhagen Mental Health Services; and the Institute of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Copenhagen; iPSYCH - The Lundbeck Foundation's Initiative for Integrative Psychiatric Research, Roskilde, Denmark (Werge).
Lundbeck (Denmark) · DKMental Health Services · DKUniversity of Copenhagen · DKLundbeck Foundation · DKUniversity of Cambridge · GBBridge University · SS
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe hemizygous 22q11.2 microdeletion is a common copy number variant in humans. The deletion confers high risk for neurodevelopmental disorders, including autism and schizophrenia. Up to 41% of deletion carriers experience psychotic symptoms.
methodsWe present a new mouse model (Df(h22q11)/+) of the deletion syndrome (22q11.2DS) and report on, to our knowledge, the most comprehensive study undertaken to date in 22q11.2DS models. The study was conducted in male mice.
resultsWe found elevated postpubertal LIMITATIONS: The 22q11.2 microdeletion has incomplete penetrance in humans, and the severity of disease depends on the complete genetic makeup in concert with environmental factors. In order to obtain more marked phenotypes reflecting the severe conditions related to 22q11.2DS it is suggested to expose the Df(h22q11)/+ mice to environmental stressors that may unmask latent psychopathology.
conclusionThe Df(h22q11)/+ model will be a valuable tool for increasing our understanding of the etiology of schizophrenia and other psychiatric disorders associated with the 22q11DS.
Indexed as
3,4-Dihydroxyphenylacetic AcidAgingAnimalsAuditory PerceptionCorpus StriatumDiGeorge SyndromeDisease Models, AnimalEvoked Potentials, Auditory, Brain StemExcitatory Amino Acid AntagonistsMaleMice, Inbred C57BLMotor ActivityPrefrontal CortexReceptors, AMPAReceptors, N-Methyl-D-AspartateReflex, Startle3,4-Dihydroxyphenylacetic AcidExcitatory Amino Acid AntagonistsReceptors, AMPAReceptors, N-Methyl-D-Aspartate
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