ArticleHuman brain mapping2016
Pain networks from the inside: Spatiotemporal analysis of brain responses leading from nociception to conscious perception.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
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Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis of neuroimaging studies on pain empathy: investigating the role of visual information and observers' perspective.Social cognitive and affective neuroscience · 2019Pooled it
- The modulation of neural insular activity by a brain computer interface differentially affects pain discrimination.Scientific reports · 2021Trial
- Brain activity sustaining the modulation of pain by empathetic comments.Scientific reports · 2019Trial
- Connectivity differences between Gulf War Illness (GWI) phenotypes during a test of attention.PloS one · 2019Trial
- Gender differences in functional connectivities between insular subdivisions and selective pain-related brain structures.The journal of headache and pain · 2018Trial
- Contact heat evoked potentials as a measure of the analgesic component of anesthesia - a patient study.Journal of clinical monitoring and computing · 2026Article
- Modulation of Posterior Insula Selectively Enhances Nociceptive Sensory Gating in Humans.medRxiv : the preprint server for health sciences · 2026Article
- Review
- The causal efficacy of consciousness: a neuroscientific analysis and explanation.Frontiers in human neuroscience · 2026Article
- Article
- Article
- Neurophysiology of acute and chronic pain: from genes to pain symptoms.BJA education · 2025Review
- Article
- Brain functional imaging contributions in osteoarthritis-related pain: A viewpoint.Osteoarthritis and cartilage open · 2025Article
- Recognition and treatment of attention deficit-hyperactivity disorder in patients with treatment-resistant burning mouth syndrome: a retrospective case study.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- A distributed brain response predicting the facial expression of acute nociceptive pain.eLife · 2024Article
- Article
- Modulation of multisensory nociceptive neurons in monkey cortical area 7b and behavioral correlates.Journal of neurophysiology · 2024Article
- Modulating Neural Circuits of Pain in Preclinical Models: Recent Insights for Future Therapeutics.Cells · 2024Review
- A distributed brain response predicting the facial expression of acute nociceptive pain.bioRxiv : the preprint server for biology · 2024Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conscious perception of painful stimuli needs the contribution of an extensive cortico-subcortical network, and is completed in less than one second. While initial activities in operculo-insular and mid-cingulate cortices have been extensively assessed, the activation timing of most areas supporting conscious pain has barely been studied. Here we used intracranial EEG to investigate the dynamics of 16 brain regions (insular, parietal, prefrontal, cingulate, hippocampal and limbic) during the first second following nociceptive-specific laser pulses. Three waves of activation could be defined according to their temporal relation with conscious perception, ascertained by voluntary motor responses. Pre-conscious activities were recorded in the posterior insula, operculum, mid-cingulate and amygdala. Antero-insular, prefrontal and posterior parietal activities started later and developed during time-frames consistent with conscious voluntary reactions. Responses from hippocampus, perigenual and perisplenial cingulate developed latest and persisted well after conscious perception occurred. Nociceptive inputs reach simultaneously sensory and limbic networks, probably through parallel spino-thalamic and spino-parabrachial pathways, and the initial limbic activation precedes conscious perception of pain. Access of sensory information to consciousness develops concomitant to fronto-parietal activity, while late-occurring responses in the hippocampal region, perigenual and posterior cingulate cortices likely underlie processes linked to memory encoding, self-awareness and pain modulation. Hum Brain Mapp 37:4301-4315, 2016. © 2016 Wiley Periodicals, Inc.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.