ArticleInternational journal of cardiology2016
Post-operative atrial fibrillation is associated with a pre-existing structural and electrical substrate in human right atrial myocardium.
Article in International journal of cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Colchicine for Prevention of Post-Cardiac Surgery and Post-Pulmonary Vein Isolation Atrial Fibrillation: A Meta-Analysis.Reviews in cardiovascular medicine · 2022Pooled it
- Association between preoperative pan-immune-inflammation value and postoperative atrial fibrillation after scheduled video-assisted thoracoscopic lobectomy.General thoracic and cardiovascular surgery · 2026Article
- Cancer as a Hidden Catalyst: Rethinking Postoperative Atrial Fibrillation After Cardiac Surgery.Journal of clinical medicine · 2026Review
- Post-Operative Atrial Fibrillation: Novel Predictive Value of CT-Derived Adipose Tissue Density in Minimally Invasive Mitral Surgery.Physiological research · 2025Article
- Integrative Evaluation of Atrial Function and Electromechanical Coupling as Predictors of Postoperative Atrial Fibrillation.Medicina (Kaunas, Lithuania) · 2025Article
- Macrophage-mediated IL-6 signaling drives ryanodine receptor-2 calcium leak in postoperative atrial fibrillation.The Journal of clinical investigation · 2025Article
- Echocardiographic Predictors of Postoperative Atrial Fibrillation After Cardiac Surgery: Assessing Atrial Mechanics for Risk Stratification.Journal of cardiovascular development and disease · 2025Article
- Analysis of selected cytokines, NLRP3 inflammasome and α-Klotho protein in patients with heart failure after ICD/CRT-D high-voltage intervention.Frontiers in physiology · 2025Article
- Postoperative atrial fibrillation (POAF) after cardiac surgery: clinical practice review.Journal of thoracic disease · 2024Review
- Identification of Atrial Transmural Conduction Inhomogeneity Using Unipolar Electrogram Morphology.Journal of clinical medicine · 2024Article
- Strain Echocardiography to Predict Postoperative Atrial Fibrillation.International journal of molecular sciences · 2022Review
- Anti-Arrhythmic Effects of Sodium-Glucose Co-Transporter 2 Inhibitors.Frontiers in pharmacology · 2022Review
- Colchicine for prevention of post-operative atrial fibrillation: Meta-analysis of randomized controlled trials.Frontiers in cardiovascular medicine · 2022Article
- Altered atrial cytosolic calcium handling contributes to the development of postoperative atrial fibrillation.Cardiovascular research · 2021Article
- Sarcolipin Exhibits Abundant RNA Transcription and Minimal Protein Expression in Horse Gluteal Muscle.Veterinary sciences · 2020Article
- Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation.Circulation research · 2020Article
- Simultaneous Endo-Epicardial Mapping of the Human Right Atrium: Unraveling Atrial Excitation.Journal of the American Heart Association · 2020Article
- Postoperative atrial fibrillation: mechanisms, manifestations and management.Nature reviews. Cardiology · 2019Review
- Article
- Entropy Mapping Approach for Functional Reentry Detection in Atrial Fibrillation: An In-Silico Study.Entropy (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPost-operative atrial fibrillation (POAF) is a major health economic burden. However, the precise mechanisms in POAF remain unclear. In other forms of AF, sites of high dominant frequency (DF) in sinus rhythm (SR) may harbour 'AF nests'. We studied AF inducibility in relation to substrate changes using epicardial electrograms and cardiomyocyte calcium handling in the atria of AF naïve patients.
methodBipolar electrograms were recorded from the lateral right atrial (RA) wall in 34 patients undergoing coronary surgery using a high-density array in sinus rhythm (NSR). RA burst pacing at 200/500/1000ms cycle lengths (CL) was performed, recording episodes of AF>30s. Co-localised RA tissue was snap frozen for RNA and protein extraction.
resultsElectrograms prolonged during AF (76.64±29.35ms) vs. NSR/pacing (p<0.001). Compared to NSR, electrogram amplitude was reduced during AF and during pacing at 200ms CL (p<0.001). Electrogram DF was significantly lower in AF (75.87±23.63Hz) vs. NSR (89.33±25.99Hz) (p<0.05), and NSR DF higher in AF inducible patients at the site of AF initiation (p<0.05). Structurally, POAF atrial myocardium demonstrated reduced sarcolipin gene (p=0.0080) and protein (p=0.0242) expression vs. NSR. Phospholamban gene and protein expression was unchanged. SERCA2a protein expression remained unchanged, but MYH6 (p=0.0297) and SERCA2A (p=0.0343) gene expression was reduced in POAF.
conclusionsHuman atrial electrograms prolong and reduce in amplitude in induced peri-operative AF vs. NSR or pacing. In those sustaining AF, high DF sites in NSR may indicate 'AF nests'. This electrical remodelling is accompanied by structural remodelling with altered expression of cardiomyocyte calcium handling detectable before POAF. These novel upstream substrate changes offer a novel mechanism and manifestation of human POAF.
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