ReviewCurrent opinion in structural biology2016
Targeting recognition surfaces on natural proteins with peptidic foldamers.
Review in Current opinion in structural biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 87 citations in OpenAlex.
- De Novo Design of Multivalent α/β-Peptides Mimicking Transcription Factors Targeting the CBP KIX Domain.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Betaine-Conjugated ß-Peptide Foldamers: Influence of Quaternary Charge on Self-Organization and MorphologyFormation.ChemistryOpen · 2025Article
- Photoresponsive Helical Foldamers: Conformational Control Through Double Helix Formation and Light-Induced Protonation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Site-directed allostery perturbation to probe the negative regulation of hypoxia inducible factor-1α.RSC chemical biology · 2024Article
- Foldamers controlled by functional triamino acids: structural investigation of α/γ-hybrid oligopeptides.Communications chemistry · 2024Article
- Visible-Light Driven Control Over Triply and Quadruply Hydrogen-Bonded Supramolecular Assemblies.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Differential membrane binding of α/β-peptide foldamers: implications for cellular delivery and mitochondrial targeting.Australian journal of chemistry · 2023Article
- Promiscuity mapping of the S100 protein family using a high-throughput holdup assay.Scientific reports · 2022Article
- Human defensin-inspired discovery of peptidomimetic antibiotics.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Supramolecular Self-Assembly of βChemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- NMR Spectroscopy of supramolecular chemistry on protein surfaces.Beilstein journal of organic chemistry · 2020Review
- Ureidopeptide GLP-1 analogues with prolonged activityChemical science · 2019Article
- Recognition of Class II MHC Peptide Ligands That Contain β-Amino Acids.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Translation of Diverse Aramid- and 1,3-Dicarbonyl-peptides by Wild Type RibosomesACS central science · 2019Article
- Fluoro-Aryl Substituted α,βFrontiers in chemistry · 2019Article
- Novel Materials From the Supramolecular Self-Assembly of Short Helical βFrontiers in chemistry · 2019Review
- Receptor selectivity from minimal backbone modification of a polypeptide agonist.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A Thermodynamic Model for Multivalency in 14-3-3 Protein-Protein Interactions.Journal of the American Chemical Society · 2018Article
- Thermodynamic Scale of β-Amino Acid Residue Propensities for an α-Helix-like Conformation.Journal of the American Chemical Society · 2018Article
- Conformationally Programmable Chiral Foldamers with Compact and Extended Domains Controlled by Monomer Structure.Angewandte Chemie (International ed. in English) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Molecules intended to antagonize protein-protein interactions or augment polypeptide-based signaling must bind tightly to large and specific surfaces on target proteins. Some types of unnatural oligomers with discrete folding propensities ('foldamers') have recently been shown to display this capability. This review covers important recent advances among several classes of foldamers, including α-peptides with secondary structures stabilized by covalent bonds, d-α-peptides, α/β-peptides and oligo-oxopiperazines. Recent advances in this area have involved enhancing membrane permeability to provide access to intracellular protein targets, improving pharmacokinetics and duration of action in vivo, and developing strategies appropriate for targeting large and irregularly-shaped protein surfaces.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.