Evidence map›Paper›PMID 27390774›Full record

ArticleeNeuro

Frontostriatal Circuit Dynamics Correlate with Cocaine Cue-Evoked Behavioral Arousal during Early Abstinence.

Wesley C Smith, Matthew H Rosenberg, Leslie D Claar, Victoria Chang, Sagar N Shah, Wendy M Walwyn, Christopher J Evans, Sotiris C Masmanidis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. A sex-dependent role for the prelimbic cortex in impulsive action both before and following early cocaine abstinence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Wesley C SmithInterdepartmental PhD Program in Neuroscience, University of California, Los Angeles , Los Angeles, California 90095.ORCID 0000-0002-7361-7760
Matthew H RosenbergDepartment of Neurobiology, University of California, Los Angeles , Los Angeles, California 90095.ORCID 0000-0002-8055-9343
Leslie D ClaarDepartment of Bioengineering, University of California, Los Angeles , Los Angeles, California 90095.ORCID 0000-0002-4030-9171
Victoria ChangUndergraduate Interdepartmental Program for Neuroscience, University of California, Los Angeles , Los Angeles, California 90095.ORCID 0000-0003-4202-8311
Sagar N ShahUndergraduate Interdepartmental Program for Neuroscience, University of California, Los Angeles , Los Angeles, California 90095.
Wendy M WalwynDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095; Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095; Hatos Center for Neuropharmacology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California 90095.ORCID 0000-0003-1192-3065
Christopher J EvansDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095; Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095; Hatos Center for Neuropharmacology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California 90095.
Sotiris C MasmanidisInterdepartmental PhD Program in Neuroscience, University of California, Los Angeles, Los Angeles, California 90095; Department of Neurobiology, University of California, Los Angeles, Los Angeles, California 90095; Department of Bioengineering, University of California, Los Angeles, Los Angeles, California 90095; Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095; California Nanosystems Institute, University of California, Los Angeles, Los Angeles, California 90095.
University of California, Los Angeles · USCalifornia NanoSystems Institute · US

Funding

UCLA Training Program in Translational Neuroscience of Drug Abuse (TNDA)T32DA024635 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY, Kate M Wassum · 2008 to 2026
$6.2M
Systems-level electrophysiology for addiction and reward researchR01DA034178 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MASMANIDIS, SOTIRIS · 2012 to 2016
$1.5M
NIDA NIH HHS R01 DA034178NIDA NIH HHS T32 DA024635
6 · The paper itself

Abstract

It is thought that frontostriatal circuits play an important role in mediating conditioned behavioral responses to environmental stimuli that were previously encountered during drug administration. However, the neural correlates of conditioned responses to drug-associated cues are not well understood at the level of large populations of simultaneously recorded neurons, or at the level of local field potential (LFP) synchrony in the frontostriatal network. Here we introduce a behavioral assay of conditioned arousal to cocaine cues involving pupillometry in awake head-restrained mice. After just 24 h of drug abstinence, brief exposures to olfactory stimuli previously paired with cocaine injections led to a transient dilation of the pupil, which was greater than the dilation effect to neutral cues. In contrast, there was no cue-selective change in locomotion, as measured by the rotation of a circular treadmill. The behavioral assay was combined with simultaneous recordings from dozens of electrophysiologically identified units in the medial prefrontal cortex (mPFC) and ventral striatum (VS). We found significant relationships between cocaine cue-evoked pupil dilation and the proportion of inhibited principal cells in the mPFC and VS. Additionally, LFP coherence analysis revealed a significant correlation between pupillary response and synchrony in the 25-45 Hz frequency band. Together, these results show that pupil dilation is sensitive to drug-associated cues during acute stages of abstinence, and that individual animal differences in this behavioral arousal response can be explained by two complementary measures of frontostriatal network activity.

Indexed as

Action PotentialsAnimalsArousalCocaineCocaine-Related DisordersConditioning, PsychologicalCortical SynchronizationCuesDopamine Uptake InhibitorsMaleMice, Inbred C57BLMotor ActivityNeural InhibitionNeural PathwaysNeuronsPrefrontal CortexCocaineDopamine Uptake Inhibitorscocaineconditioned arousallarge-scale recordingsprefrontal cortexpupillometrystriatum

Identifiers

PMID27390774
PMCPMC4917735
OpenAlexW2425778962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.