ArticleInternational journal of women's health2016
Amniotic membrane can be a valid source for wound healing.
Article in International journal of women's health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Advancements in cell-based therapies for thermal burn wounds: a comprehensive systematic review of clinical trials outcomes.Stem cell research & therapy · 2024Pooled it
- Dressings and topical agents for treating venous leg ulcers.The Cochrane database of systematic reviews · 2018Pooled it
- A Biologic and Physical Characterization of an Injectable Amniotic Membrane Designed for Treating Diabetic Foot Ulcers.Bioengineering (Basel, Switzerland) · 2024Article
- The Collection and Application of Autologous Amniotic Fluid to Cesarean Delivery Closure.AJP reports · 2024Article
- Efficacy of Type-1 Fish Collagen Membrane v/s Human Amniotic Membrane as a Surgical Dressing Material in Maxillofacial Wounds: A Comparative Study.Journal of maxillofacial and oral surgery · 2024Article
- The Use of Human Amniotic Membrane Tissue Grafting in Acute Traumatic Finger Injury: A Case Report.Cureus · 2024Article
- USE OF DECELLULARIZED HUMAN AMNIOTIC MEMBRANE IN INTESTINAL ANASTOMOSES: A STUDY IN RATS TREATED WITH 5-FLUOROURACIL.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2024Article
- Treatment Challenges in a Pregnant Patient With Severe Burn Injury and Wound Care Using Amniotic Membrane: A Case Report.Annals of burns and fire disasters · 2023Article
- Outcome of Application of Cryopreserved Amniotic Membrane Grafts in the Treatment of Chronic Nonhealing Wounds of Different Origins in Polymorbid Patients: A Prospective Multicenter Study.Bioengineering (Basel, Switzerland) · 2023Article
- Quantification of Analgesic and Anti-Inflammatory Lipid Mediators in Long-Term Cryopreserved and Freeze-Dried Preserved Human Amniotic Membrane.Bioengineering (Basel, Switzerland) · 2023Article
- Distribution of an analgesic palmitoylethanolamide and other N-acylethanolamines in human placental membranes.PloS one · 2023Article
- Strategies for immortalisation of amnion-derived mesenchymal and epithelial cells.Cell biology international · 2022Review
- Healing of a chronic ulcer of the lower limb of venous origin with fresh human amniochorionic membrane allograftBiomedica : revista del Instituto Nacional de Salud · 2022Article
- Mesenchymal stem cells' seeded amniotic membrane as a tissue-engineered dressing for wound healing.Drug delivery and translational research · 2022Article
- Biophysical Characterization of a Novel Tri-Layer Placental Allograft Membrane.Advances in wound care · 2022Article
- Clinical application of both amniotic membranes and adipose derived mesenchymal stem cells in a cat with a large skin defect.Veterinarni medicina · 2022Article
- Placental Tissues as Biomaterials in Regenerative Medicine.BioMed research international · 2022Review
- Human Placental Mesenchymal Stem Cells for the Treatment of ARDS in Rat.Stem cells international · 2022Article
- Third-degree full-thickness burns as a complication of cervical radiofrequency ablation.BMJ case reports · 2021Article
- Aligned Poly(ε-caprolactone) Nanofibers Superimposed on Decellularized Human Amniotic Membrane Promoted Myogenic Differentiation of Adipose Derived Stem Cells.Cell journal · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledAmniotic membrane (AM) can promote proper epithelialization with suppression of excessive fibrosis by creating a supportive milieu for regeneration of chronic ulcer bed.
objectiveThe objective of this study is to investigate whether AM scaffold can modulate the healing of a wound by promoting tissue reconstruction rather than promoting scar tissue formation. SUBJECTS AND
methodsAM was obtained and prepared and then applied to patients with chronic leg ulcers who were randomly divided into two different groups. Group I (control group) included eleven patients in whom ulcers were treated with conventional wound dressings that were changed daily for 8 weeks. Group II (study group) included 14 patients in whom the AM was placed in contact with the ulcer and held in place with a secondary dressing, which was changed daily. Follow-up was done to detect healing rate and detection of ulcer size, assessment of pain, and to take ulcer images (days 0, 7, 14, 21, 30, 45, and 60).
resultsIn group I, all ulcers showed no reduction in their size, and ulcer floor remained the same. Healthy granulations were present in two ulcers (18.2%) and absent in nine ulcers (81.8%). There was no improvement of pain level in the eleven ulcers. In group II, complete healing of 14 ulcers occurred in 14-60 days with a mean of 33.3±14.7; healing rate range was 0.064-2.22 and the mean 0.896±0.646 cm(2)/day. Healthy granulations were present in 13 ulcers (92.9%) and absent in one ulcer (7.1%). Three ulcers (21.4%) were of mild severity (grade 1 ulcers) while eleven ulcers (78.6%) were of moderate severity (grade 2 ulcers). The healing rate was faster in ulcers of mild severity (1.7±0.438 cm(2)/day) in comparison to ulcers of moderate severity (0.673±0.498 cm(2)/day). Eleven cases (78.6%) showed improvement in their pain level on a scale from 0 to 10.
conclusionAM graft can be of value in wound healing. Further studies are needed to confirm these findings.
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