ArticleMedical science monitor : international medical journal of experimental and clinical research2016
Percentage of Peripheral CD19+CD24hiCD38hi Regulatory B Cells in Neonatal Sepsis Patients and Its Functional Implication.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Trial
- B-cell dynamics during experimental endotoxemia in humans.Bioscience reports · 2019Trial
- Transcriptomic signatures of neonatal acute respiratory distress syndrome in a prospective cohort of respiratory distress.iScience · 2025Article
- Regulatory B cells attenuate sepsis-associated pancreatic injury by regulating T cell homeostasis.Scientific reports · 2025Article
- B-Cell-Activating Factor Contributes to Elevation of the Content of Regulatory B Cells in Neonatal Sepsis.Bulletin of experimental biology and medicine · 2023Article
- Diagnostic and predictive values of pyroptosis-related genes in sepsis.Frontiers in immunology · 2023Article
- CD19BMC immunology · 2022Article
- The emerging roles and therapeutic potential of B cells in sepsis.Frontiers in pharmacology · 2022Review
- Advances in Immune Monitoring Approaches for Sepsis-Induced Immunosuppression.Frontiers in immunology · 2022Review
- Characterization of human peripheral blood γδ T cells in patients with sepsis.Experimental and therapeutic medicine · 2020Article
- Levels and Clinical Significance of Regulatory B Cells and T Cells in Acute Myeloid Leukemia.BioMed research international · 2020Article
- Characterization of Circulating IL-10-Producing Cells in Septic Shock Patients: A Proof of Concept Study.Frontiers in immunology · 2020Article
- The effects of umblical cord clamping time on lymphocyte subgroups in term and late preterm infants.Turk pediatri arsivi · 2018Article
- Advances in the understanding and treatment of sepsis-induced immunosuppression.Nature reviews. Nephrology · 2018Review
- Unique aspects of the perinatal immune system.Nature reviews. Immunology · 2017Review
- Clinical significance of Vδ1 T cell detection in sepsis patients.International journal of clinical and experimental pathology · 2017Article
- Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization.Frontiers in immunology · 2017Article
- IL-10-Producing B Cells Suppress Effector T Cells Activation and Promote Regulatory T Cells in Crystalline Silica-Induced Inflammatory Response In Vitro.Mediators of inflammation · 2017Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND As a major cause of mortality in neonates, neonatal sepsis is often accompanied by immune dysfunctions, which are frequently caused by dysregulated T cell sub-populations. The role of regulatory B cells in neonatal sepsis, however, remains unknown. Therefore, this study investigated the percentage and functional variation of CD19+CD24hiCD38hi regulatory B cells in peripheral blood of neonatal sepsis patients in an attempt to elucidate the role of these regulatory B cells in pathogenesis of sepsis. MATERIAL AND METHODS Flow cytometry was used to quantify the percentage of CD19+CD24hiCD38hi regulatory B cells from peripheral blood samples. The correlation between B cell percentage and C reactive protein (CRP) level was analyzed. Secretion level of interleukin-10 (IL-10) and effects on the proliferation of naïve CD4+ T cells were further analyzed. RESULTS The percentage of CD19+CD24hiCD38hi regulatory B cells in neonatal sepsis patients was significantly higher compared to healthy controls (p<0.05), and was positively correlated with serum CRP level. The percentage of IL-10+ CD19+CD24hiCD38hi regulatory B cells was also higher in sepsis patients, and also had more potent inhibition on naïve CD4+ T cells (p<0.01). CONCLUSIONS The elevation of CD19+CD24hiCD38hi regulatory B cells in neonatal sepsis can inhibit body immune function and thus may participate in the pathogenesis of sepsis.
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