Evidence map›Paper›PMID 27389907›Full record

ReviewEuropean heart journal2017

Catheter ablation in patients with persistent atrial fibrillation.

Paulus Kirchhof, Hugh Calkins

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in European heart journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04190186 (Hybrid Ablation Plus Medical Therapy for Persistent Atrial Fibrillation), which is not on this map. Cited by 54 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 3 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04190186 nacompletednot on this mapstarted 2020, after this paper: background citation

Hybrid Ablation Plus Medical Therapy for Persistent Atrial Fibrillation (HYBRID AF)

TypeinterventionalSponsorUniversity of RochesterRan2020 to 2024Enrolled55ConditionsPersistent Atrial FibrillationArmsInsertable Cardiac Monitor
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 152 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Clinical scores for outcomes of rhythm control or arrhythmia progression in patients with atrial fibrillation: a systematic review.Clinical research in cardiology : official journal of the German Cardiac Society · 2017
    Pooled it
  4. Trial
  5. Review
  6. Optimising the atrial fibrillation ablation pathway using vascular closure devices: effects on length of stay, procedure time and outcomes.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026
    Article
  7. Fto-mediated m6A demethylation of Lox drives atrial fibrosis and promotes atrial fibrillation in a murine model of hyperthyroidism.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  8. Review
  9. Persistent atrial fibrillation ablation: glimpsing the light ahead?Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Review
  10. Article
  11. Functional substrate analysis in patients with persistent atrial fibrillation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Pulmonary vein isolation with the radiofrequency balloon catheter: a single centre prospective study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 3 countries.

Paulus KirchhofInstitute of Cardiovascular Sciences, University of Birmingham, IBR, Room # 136, Birmingham B15 2TT, UK p.kirchhof@bham.ac.uk.
Hugh CalkinsJohns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · USUniversity Hospital Münster · DE

Funding

British Heart Foundation FS/13/43/30324
6 · The paper itself

Abstract

Catheter ablation is increasingly offered to patients who suffer from symptoms due to atrial fibrillation (AF), based on a growing body of evidence illustrating its efficacy compared with antiarrhythmic drug therapy. Approximately one-third of AF ablation procedures are currently performed in patients with persistent or long-standing persistent AF. Here, we review the available information to guide catheter ablation in these more chronic forms of AF. We identify the following principles: Our clinical ability to discriminate paroxysmal and persistent AF is limited. Pulmonary vein isolation is a reasonable and effective first approach for catheter ablation of persistent AF. Other ablation strategies are being developed and need to be properly evaluated in controlled, multicentre trials. Treatment of concomitant conditions promoting recurrent AF by life style interventions and medical therapy should be a routine adjunct to catheter ablation of persistent AF. Early rhythm control therapy has a biological rationale and trials evaluating its value are underway. There is a clear need to generate more evidence for the best approach to ablation of persistent AF beyond pulmonary vein isolation in the form of adequately powered controlled multi-centre trials.

Indexed as

Anti-Arrhythmia AgentsAtrial FibrillationCardiac Resynchronization TherapyCatheter AblationChronic DiseaseHeart AtriaHumansPulmonary VeinsSecondary PreventionTreatment OutcomeAnti-Arrhythmia AgentsAntiarrhythmic drugsAtrial fibrillationCatheter ablationClinical practiceComplicationsExerciseIndicationsLong-standing persistentOutcomesPersistentRhythm control therapySinus rhythmTechniqueUpstream therapyWeight loss

Identifiers

PMID27389907
PMCPMC5353871
OpenAlexW2473846526

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.