Evidence map›Paper›PMID 27389800›Full record

ArticleCortex; a journal devoted to the study of the nervous system and behavior2016

Reading words and other people: A comparison of exception word, familiar face and affect processing in the left and right temporal variants of primary progressive aphasia.

Richard J Binney, Maya L Henry, Miranda Babiak, Peter S Pressman, Miguel A Santos-Santos, Jared Narvid, Maria Luisa Mandelli, Paul J Strain, Bruce L Miller, Katherine P Rankin and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Multimodal semantic knowledge of emotion concepts in frontotemporal dementia.medRxiv : the preprint server for health sciences · 2026
    Article
  8. Article
  9. Review
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  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Neural correlates of empathy in mild cognitive impairment.Cognitive, affective & behavioral neuroscience · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Richard J BinneyMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA. Electronic address: Richard.Binney@Temple.edu.
Maya L HenryMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Miranda BabiakMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Peter S PressmanMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Miguel A Santos-SantosMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Jared NarvidMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Maria Luisa MandelliMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Paul J StrainMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Bruce L MillerMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Katherine P RankinMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Howard J RosenMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Maria Luisa Gorno-TempiniMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
University of California, San Francisco · US

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
Progressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0M
The Frontotemporal Lobar Degeneration Neuroimaging InitiativeR01AG032306 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSEN, HOWARD J · 2009 to 2013
$10.0M
Connectomic imaging in familial and sporadic frontotemporal degenerationU01AG052943 · NIA · UNIVERSITY OF PENNSYLVANIA · PI GORNO TEMPINI, MARIA LUISA, GROSSMAN, MURRAY · 2016 to 2019
$5.9M
Attention and Semantic Evaluation as Predictors of Empathy in Healthy Aging and Frontotemporal DementiaRF1AG029577 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANKIN, KATHERINE P · 2019 to 2019
$4.0M
Measuring Altered Social Behavior in Neurodegenerative DiseaseR01AG029577 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANKIN, KATHERINE P · 2008 to 2018
$3.6M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
Multimodal Imaging in Frontotemporal DegenerationK24AG045333 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSEN, HOWARD J · 2013 to 2023
$1.9M
NIA NIH HHS K24 AG045333NIA NIH HHS P01 AG019724NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG032306NIA NIH HHS RF1 AG029577NIA NIH HHS U01 AG052943NIDCD NIH HHS K24 DC015544NINDS NIH HHS R01 NS050915
6 · The paper itself

Abstract

Semantic variant primary progressive aphasia (svPPA) typically presents with left-hemisphere predominant rostral temporal lobe (rTL) atrophy and the most significant complaints within the language domain. Less frequently, patients present with right-hemisphere predominant temporal atrophy coupled with marked impairments in processing of famous faces and emotions. Few studies have objectively compared these patient groups in both domains and therefore it is unclear to what extent the syndromes overlap. Clinically diagnosed svPPA patients were characterized as left- (n = 21) or right-predominant (n = 12) using imaging and compared along with 14 healthy controls. Regarding language, our primary focus was upon two hallmark features of svPPA; confrontation naming and surface dyslexia. Both groups exhibited naming deficits and surface dyslexia although the impairments were more severe in the left-predominant group. Familiarity judgments on famous faces and affect processing were more profoundly impaired in the right-predominant group. Our findings suggest that the two syndromes overlap significantly but that early cases at the tail ends of the continuum constitute a challenge for current clinical criteria. Correlational neuroimaging analyses implicated a mid portion of the left lateral temporal lobe in exception word reading impairments in line with proposals that this region is an interface between phonology and semantic knowledge.

Indexed as

ReadingSocial PerceptionAgedAphasia, Primary ProgressiveFacial RecognitionFemaleHumansLanguageMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsPattern Recognition, VisualRecognition, PsychologyTemporal LobeAnterior temporal lobePrimary progressive aphasiaSemantic dementiaSocial cognitionSurface dyslexia

Identifiers

PMID27389800
PMCPMC4969161
OpenAlexW2417185622

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.