ArticleNeuroImage2016
Biophysical modeling of high field diffusion MRI demonstrates micro-structural aberration in chronic mild stress rat brain.
Article in NeuroImage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
32 citing papers in PubMed, 58 citations in OpenAlex.
- Pathogenic O-GlcNAc dyshomeostasis is associated with cortical malformations and hyperactivity.eLife · 2026Article
- Comprehensive Analysis of the 5xFAD Mouse Model of Alzheimer's Disease Using dMRI, Immunohistochemistry, and Neuronal and Glial Functional Metabolic Mapping.Biomolecules · 2024Article
- Translational models of stress and resilience: An applied neuroscience methodology review.Neuroscience applied · 2024Review
- The effects of locus coeruleus ablation on mouse brain volume and microstructure evaluated by high-field MRI.Frontiers in cellular neuroscience · 2024Article
- Biophysical modeling and diffusion kurtosis imaging reveal microstructural alterations in normal-appearing white-matter regions of the brain in obstructive sleep apnea.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Cerebral Microstructural and Microvascular Changes in Non-Neuropsychiatric Systemic Lupus Erythematosus: A Study Using Diffusion Kurtosis Imaging and 3D Pseudo-Continuous Arterial Spin Labeling.Journal of inflammation research · 2023Article
- White Matter Changes Following Chronic Restraint Stress and Neuromodulation: A Diffusion Magnetic Resonance Imaging Study in Young Male Rats.Biological psychiatry global open science · 2022Article
- Investigating the contribution of cytoarchitecture to diffusion MRI measures in gray matter using histology.Frontiers in neuroimaging · 2022Article
- A Preliminary Quantitative Electron Microscopic Analysis Reveals Reduced Number of Mitochondria in the Infralimbic Cortex of Rats Exposed to Chronic Mild Stress.Frontiers in behavioral neuroscience · 2022Article
- Combined diffusion-relaxometry microstructure imaging: Current status and future prospects.Magnetic resonance in medicine · 2021Review
- Rapid microstructural plasticity in the cortical semantic network following a short language learning session.PLoS biology · 2021Article
- Neuroanatomical underpinning of diffusion kurtosis measurements in the cerebral cortex of healthy macaque brains.Magnetic resonance in medicine · 2021Article
- Leakage of astrocyte-derived extracellular vesicles in stress-induced exhaustion disorder: a cross-sectional study.Scientific reports · 2021Article
- Distinct Features of Cerebral Blood Flow and Spontaneous Neural Activity as Integrated Predictors of Early Response to Antidepressants.Frontiers in psychiatry · 2021Article
- Review
- Stress-Induced Microstructural Alterations Correlate With the Cognitive Performance of Rats: A LongitudinalFrontiers in neuroscience · 2020Article
- Diffusion Kurtosis Imaging as a Tool in Neurotoxicology.Neurotoxicity research · 2020Article
- Diffusion kurtosis imaging of gray matter in schizophrenia.Cortex; a journal devoted to the study of the nervous system and behavior · 2019Article
- Diffusion Kurtosis Imaging Detects Microstructural Changes in a Methamphetamine-Induced Mouse Model of Parkinson's Disease.Neurotoxicity research · 2019Article
- An Introduction to Kurtosis Fractional Anisotropy.AJNR. American journal of neuroradiology · 2019Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Depression is one of the leading causes of disability worldwide. Immense heterogeneity in symptoms of depression causes difficulty in diagnosis, and to date, there are no established biomarkers or imaging methods to examine depression. Unpredictable chronic mild stress (CMS) induced anhedonia is considered to be a realistic model of depression in studies of animal subjects. Stereological and neuronal tracing techniques have demonstrated persistent remodeling of microstructure in hippocampus, prefrontal cortex and amygdala of CMS brains. Recent developments in diffusion MRI (d-MRI) analyses, such as neurite density and diffusion kurtosis imaging (DKI), are able to capture microstructural changes and are considered to be robust tools in preclinical and clinical imaging. The present study utilized d-MRI analyzed with a neurite density model and the DKI framework to investigate microstructure in the hippocampus, prefrontal cortex, caudate putamen and amygdala regions of CMS rat brains by comparison to brains from normal controls. To validate findings of CMS induced microstructural alteration, histology was performed to determine neurite, nuclear and astrocyte density. d-MRI based neurite density and tensor-based mean kurtosis (MKT) were significantly higher, while mean diffusivity (MD), extracellular diffusivity (Deff) and intra-neurite diffusivity(D
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.