ArticlePLoS computational biology2016
Properties of Neurons in External Globus Pallidus Can Support Optimal Action Selection.
Article in PLoS computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Connectivity and Functionality of the Globus Pallidus Externa Under Normal Conditions and Parkinson's Disease.Frontiers in neural circuits · 2021Pooled it
- Cognitive functions of the GPe.Trends in neurosciences · 2026Review
- How cortico-basal ganglia-thalamic subnetworks can shift decision policies to increase reward rate.PLoS computational biology · 2025Article
- Matrix-biased excitatory and inhibitory inputs to the striatum involving external segment of the globus pallidus.Frontiers in cellular neuroscience · 2025Article
- Pramipexole Hyperactivates the External Globus Pallidus and Impairs Decision-Making in a Mouse Model of Parkinson's Disease.International journal of molecular sciences · 2024Article
- Distinct basal ganglia contributions to learning from implicit and explicit value signals in perceptual decision-making.Nature communications · 2024Article
- Feasibility of dopamine as a vector-valued feedback signal in the basal ganglia.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- External globus pallidus input to the dorsal striatum regulates habitual seeking behavior in male mice.Nature communications · 2023Article
- Conflict Detection in a Sequential Decision Task Is Associated with Increased Cortico-Subthalamic Coherence and Prolonged Subthalamic Oscillatory Response in the β Band.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Making decisions in the dark basement of the brain: A look back at the GPR model of action selection and the basal ganglia.Biological cybernetics · 2021Article
- A change of mind: Globus pallidus activity and effective connectivity during changes in choice selections.The European journal of neuroscience · 2021Article
- ParvalbuminThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- Biased competition in the absence of input bias revealed through corticostriatal computation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Modeling sensory-motor decisions in natural behavior.PLoS computational biology · 2018Article
- A probabilistic, distributed, recursive mechanism for decision-making in the brain.PLoS computational biology · 2018Article
- An Approximation of the Error Backpropagation Algorithm in a Predictive Coding Network with Local Hebbian Synaptic Plasticity.Neural computation · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The external globus pallidus (GPe) is a key nucleus within basal ganglia circuits that are thought to be involved in action selection. A class of computational models assumes that, during action selection, the basal ganglia compute for all actions available in a given context the probabilities that they should be selected. These models suggest that a network of GPe and subthalamic nucleus (STN) neurons computes the normalization term in Bayes' equation. In order to perform such computation, the GPe needs to send feedback to the STN equal to a particular function of the activity of STN neurons. However, the complex form of this function makes it unlikely that individual GPe neurons, or even a single GPe cell type, could compute it. Here, we demonstrate how this function could be computed within a network containing two types of GABAergic GPe projection neuron, so-called 'prototypic' and 'arkypallidal' neurons, that have different response properties in vivo and distinct connections. We compare our model predictions with the experimentally-reported connectivity and input-output functions (f-I curves) of the two populations of GPe neurons. We show that, together, these dichotomous cell types fulfil the requirements necessary to compute the function needed for optimal action selection. We conclude that, by virtue of their distinct response properties and connectivities, a network of arkypallidal and prototypic GPe neurons comprises a neural substrate capable of supporting the computation of the posterior probabilities of actions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.