ArticleGenome biology and evolution2016
Comparison of a Modern and Fossil Pithovirus Reveals Its Genetic Conservation and Evolution.
Article in Genome biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- The Zoetrope effect in phage evolution.Frontiers in microbiology · 2026Article
- Refining the taxonomy of pithovirus-related giant DNA viruses within the order Pimascovirales.Archives of virology · 2025Article
- Host-Calibrated Time Tree Caps the Age of Giant Viruses.Molecular biology and evolution · 2025Article
- Molecular diversity of green-colored microbial mats from hot springs of northern Japan.Extremophiles : life under extreme conditions · 2024Article
- Pithoviruses Are Invaded by Repeats That Contribute to Their Evolution and Divergence from Cedratviruses.Molecular biology and evolution · 2023Article
- Analysis of the Genomic Features and Evolutionary History of Pithovirus-Like Isolates Reveals Two Major Divergent Groups of Viruses.Journal of virology · 2023Article
- Giant virus biology and diversity in the era of genome-resolved metagenomics.Nature reviews. Microbiology · 2022Review
- The Astounding World of Glycans from Giant Viruses.Chemical reviews · 2022Review
- Past and present giant viruses diversity explored through permafrost metagenomics.Nature communications · 2022Article
- Applying the concept of liquid biopsy to monitor the microbial biodiversity of marine coastal ecosystems.ISME communications · 2022Article
- Article
- Morphological and Genomic Features of the New Klosneuvirinae Isolate Fadolivirus IHUMI-VV54.Frontiers in microbiology · 2021Article
- Characterization ofJournal of virology · 2020Article
- How Tupanvirus Degrades the Ribosomal RNA of Its Amoebal Host? The Ribonuclease T2 Track.Frontiers in microbiology · 2020Article
- Isolation of Yasminevirus, the First Member of Klosneuvirinae Isolated in Coculture with Vermamoeba vermiformis, Demonstrates an Extended Arsenal of Translational Apparatus Components.Journal of virology · 2019Article
- Review
- Review
- Guarani Virophage, a New Sputnik-Like Isolate From a Brazilian Lake.Frontiers in microbiology · 2019Article
- Morphologic and Genomic Analyses of New Isolates Reveal a Second Lineage of Cedratviruses.Journal of virology · 2018Article
- Cedratvirus getuliensis replication cycle: an in-depth morphological analysis.Scientific reports · 2018Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Most theories on viral evolution are speculative and lack fossil comparison. Here, we isolated a modern Pithovirus-like virus from sewage samples. This giant virus, named Pithovirus massiliensis, was compared with its prehistoric counterpart, Pithovirus sibericum, found in Siberian permafrost. Our analysis revealed near-complete gene repertoire conservation, including horizontal gene transfer and ORFans. Furthermore, all orthologous genes evolved under strong purifying selection with a non-synonymous and synonymous ratio in the same range as the ratio found in the prokaryotic world. The comparison between fossil and modern Pithovirus species provided an estimation of the cadence of the molecular clock, reaching up to 3 × 10(-6) mutations/site/year. In addition, the strict conservation of HGTs and ORFans in P. massiliensis revealed the stable genetic mosaicism in giant viruses and excludes the concept of a bag of genes. The genetic stability for 30,000 years of P. massiliensis demonstrates that giant viruses evolve similarly to prokaryotes by classical mechanisms of evolution, including selection and fixation of genes, followed by selective constraints.
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