ArticleObesity surgery2017
Morphological Changes in the Carotid Artery Intima after Gastric Bypass for Morbid Obesity.
Article in Obesity surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03306771 (The Relationship Between Morbid Obesity and Carotid Artery Stenosis - a Comparative Prospective Study), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Relationship Between Morbid Obesity and Carotid Artery Stenosis - a Comparative Prospective Study
Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Sleeve Gastrectomy and Gastric Bypass Decrease the Carotid Intima-Media Thickness in Obese Men: Association with Weight Loss, Cardiovascular Risk Factors, and Circulating Testosterone.Obesity surgery · 2020Trial
- Early Regression of Carotid Intima-Media Thickness after Bariatric Surgery and Its Relation to Serum Leptin Reduction.Obesity surgery · 2018Trial
- Impact of bariatric surgery on carotid intima-media thickness and arterial stiffness in metabolically healthy obesity: a prospective study.Hormones (Athens, Greece) · 2024Article
- Impact on carotid intima-media thickness after laparoscopic sleeve gastrectomy in patients with morbid obesity.Surgical endoscopy · 2024Article
- Effect of Bariatric Surgery on Intima Media Thickness: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2022Review
- Impact of Bariatric Surgery on Carotid Intima-Media Thickness in Patients with Morbid Obesity: a Prospective Study and Review of the Literature.Obesity surgery · 2022Review
- Impact of bariatric surgery on carotid intima-medial thickness and cardiovascular risk: results of a prospective study.Surgical endoscopy · 2021Article
- Ockham's razor and the metabolic syndrome.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2021Review
- Assessment of Carotid Artery Distensibility and Elasticity After Laparoscopic Sleeve Gastrectomy: a Prospective Study.Obesity surgery · 2020Article
- Peripheral neuropathies after bariatric surgery. Preliminary results from a single-centre prospective study in Northern Italy.Acta bio-medica : Atenei Parmensis · 2019Article
- Abdominal pain and internal hernias after Roux-en-Y Gastric Bypass: are we dealing with the tip of an iceberg?Acta bio-medica : Atenei Parmensis · 2019Article
- Age-Related Effects of Bariatric Surgery on Early Atherosclerosis and Cardiovascular Risk Reduction.Obesity surgery · 2018Article
- Laparoscopic gastric bypass with remnant gastrectomy in a super-super obese patient with gastric metaplasia: a surgical hazard?Acta bio-medica : Atenei Parmensis · 2018Article
- Lipid changes 8 years post gastric bypass in adolescents with severe obesity (FABS-5+ study).International journal of obesity (2005) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCarotid intima-media thickness (C-IMT) can be considered as an early marker of atherosclerosis, thus representing a reliable cardiovascular risk predictor. Bariatric surgery decreases the burden of cardiovascular disease in obese patients through complex mechanisms, of which weight loss is merely the most evident epiphenomenon. The aim of this study is to evaluate C-IMT variations in patients undergoing Roux-en-Y gastric bypass (RYGB) and possible correlations with biometric parameters and cardiovascular risk factors.
methodsThirty patients undergoing RYGB for morbid obesity were enrolled for carotid artery B-mode ultrasound evaluation before surgery and at 1-, 3-, 6-, and 12-month follow-up; C-IMT was recorded at three levels (bulb, common, and internal carotid). At each one of the follow-ups, biometric and serohematic parameters were also collected.
resultsThe 22 patients who completed the follow-up and were included in the study showed significant C-IMT reduction at all three levels at 12-month follow-up (p < 0.001). Along with a significant BMI reduction and diabetes/hypertension remission, we found a considerable decrease in total cholesterol (219 vs 164 mg/dl; p < 0.001) and uric acid (5.6 vs 4.5 mg/dl; p < 0.01) and a significant increase in HDL cholesterol (43.9vs59.2 mg/dl; p < 0.001). The data imply that the mean 10-year cardiovascular risk score drops by nearly 50 % (5.7 ± 5.6 vs. 2.9 ± 2.7 %, p < 0.001) according to Framingham cardiovascular risk stratification.
conclusionsRYGB is associated with significant decrease in C-IMT at 1 year. Pathophysiologic processes underlying such a variation, probably involving lipid and urate metabolism and their correlation with cardiovascular risk reduction should be confirmed by long-term prospective trials.
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