ReviewThe Proceedings of the Nutrition Society2017
Endocrine disruption by dietary phyto-oestrogens: impact on dimorphic sexual systems and behaviours.
Review in The Proceedings of the Nutrition Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 100 citations in OpenAlex.
- Chemicals in cow milk and soy beverages: Neurotoxicity and neuroprotection.Advances in neurotoxicology · 2026Article
- Therapeutic Effects of Fermented Soy Extract on Osteoporotic Changes in Ovariectomized Mice as a Model of Menopause.Molecular nutrition & food research · 2026Article
- Attenuation of carbon tetrachloride-induced male reproductive damage in albino laboratory rats using varying concentrations of supplemented soybean.Open veterinary journal · 2026Article
- Article
- Unveiling the Endocrine-Disrupting Potential of Plant-Derived Compounds: An Ecotoxicological Review.Toxins · 2025Review
- Screening the effects of phytoestrogens on lipid metabolism in primary cultured adipocytes from rainbow trout (Oncorhynchus mykiss) and gilthead sea bream (Sparus aurata).Fish physiology and biochemistry · 2025Article
- Polyphenols Regulate the Activity of Endocrine-Disrupting Chemicals, Having Both Positive and Negative Effects.Journal of xenobiotics · 2024Review
- Endocrine-disrupting effects of bisphenol-A, thiamethoxam, and fipronil in hormone-naïve transmen compared to cis-women.Hormones (Athens, Greece) · 2024Article
- Regrettable Substitutes and the Brain: What Animal Models and Human Studies Tell Us about the Neurodevelopmental Effects of Bisphenol, Per- and Polyfluoroalkyl Substances, and Phthalate Replacements.International journal of molecular sciences · 2024Review
- Article
- Review
- Insight into the Potential Mechanisms of Endocrine Disruption by Dietary Phytoestrogens in the Context of the Etiopathogenesis of Endometriosis.International journal of molecular sciences · 2023Review
- Evaluation of The Effects of Carob (Journal of clinical research in pediatric endocrinology · 2023Article
- Phytoestrogens as Biomarkers of Plant Raw Materials Used for Fish Feed Production.Molecules (Basel, Switzerland) · 2023Article
- Recent Advances in Nano-Enabled Seed Treatment Strategies for Sustainable Agriculture: Challenges, Risk Assessment, and Future Perspectives.Nano-micro letters · 2023Review
- An extensive review on phenolic compounds and their potential estrogenic properties on skin physiology.Frontiers in cell and developmental biology · 2023Review
- The health effects of soy: A reference guide for health professionals.Frontiers in nutrition · 2022Review
- The Impact of Cereal Grain Composition on the Health and Disease Outcomes.Frontiers in nutrition · 2022Review
- Maternal exposure to genistein during pregnancy and oxidative DNA damage in testes of male mouse offspring.Frontiers in nutrition · 2022Article
- Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer's Disease.Oxidative medicine and cellular longevity · 2022Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
A wide range of health benefits have been ascribed to soya intake including a lowered risk of osteoporosis, heart disease, breast cancer, and menopausal symptoms. Because it is a hormonally active diet, however, soya can also be endocrine disrupting, suggesting that intake has the potential to cause adverse health effects in certain circumstances, particularly when exposure occurs during development. Consequently, the question of whether or not soya phyto-oestrogens are beneficial or harmful to human health is neither straightforward nor universally applicable to all groups. Possible benefits and risks depend on age, health status, and even the presence or absence of specific gut microflora. As global consumption increases, greater awareness and consideration of the endocrine-disrupting properties of soya by nutrition specialists and other health practitioners is needed. Consumption by infants and small children is of particular concern because their hormone-sensitive organs, including the brain and reproductive system, are still undergoing sexual differentiation and maturation. Thus, their susceptibility to the endocrine-disrupting activities of soya phyto-oestrogens may be especially high. As oestrogen receptor partial agonists with molecular and cellular properties similar to anthropogenic endocrine disruptors such as bisphenol A, the soya phyto-oestrogens provide an interesting model for how attitudes about what is 'synthetic' v. what is 'natural,' shapes understanding and perception of what it means for a compound to be endocrine disrupting and/or potentially harmful. This review describes the endocrine-disrupting properties of soya phyto-oestrogens with a focus on neuroendocrine development and behaviour.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.