ArticleScientific reports2016
The proneurotrophin receptor sortilin is required for Mycobacterium tuberculosis control by macrophages.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Identification of SORT1 as a Key Regulator of Antigen Presentation in CD16+ Monocytes During Septic Shock via Multi-Omics and In Silico Gene Knockout Analysis.Immunity, inflammation and disease · 2026Article
- Machine-Learning-Derived, Mechanistically Informed Transcriptomic Signature to Diagnose Active Tuberculosis and Guide Host-Directed Therapy.Diagnostics (Basel, Switzerland) · 2026Article
- Sphingosine kills Mycobacteria and suppresses mycobacterial lung infections.Journal of molecular medicine (Berlin, Germany) · 2025Article
- SORT1/LAMP2-mediated extracellular vesicle secretion and cell adhesion are linked to lenalidomide resistance in multiple myeloma.Blood advances · 2022Article
- Sphingolipids, mycobacteria and host: Unraveling the tug of war.Frontiers in immunology · 2022Article
- Identifying COVID-19-Specific Transcriptomic Biomarkers with Machine Learning Methods.BioMed research international · 2021Article
- Article
- The Macrophage Response toFrontiers in cellular and infection microbiology · 2020Review
- Mutant Huntingtin Affects Diabetes and Alzheimer's Markers in Human and Cell Models of Huntington's Disease.Cells · 2019Article
- Neisseria meningitidis Type IV Pili Trigger CaInfection and immunity · 2019Article
- Mycobacterium tuberculosis infection of host cells in space and time.FEMS microbiology reviews · 2019Review
- Gene expression profiles during subclinical Mycobacterium avium subspecies paratuberculosis infection in sheep can predict disease outcome.Scientific reports · 2019Article
- Functional inhibition of acid sphingomyelinase disrupts infection by intracellular bacterial pathogens.Life science alliance · 2019Article
- Targeting host lipid flows: Exploring new antiviral and antibiotic strategies.Cellular microbiology · 2019Review
- Crosstalk Between Acid Sphingomyelinase and Inflammasome Signaling and Their Emerging Roles in Tissue Injury and Fibrosis.Frontiers in cell and developmental biology · 2019Review
- Regulatory Roles of Sortilin and SorLA in Immune-Related Processes.Frontiers in pharmacology · 2018Review
- Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells.EMBO reports · 2017Article
- Mycobacterium bovis Requires P27 (LprG) To Arrest Phagosome Maturation and Replicate within Bovine Macrophages.Infection and immunity · 2017Article
- Macrophage-Bacteria Interactions-A Lipid-Centric Relationship.Frontiers in immunology · 2017Review
- The Macrophage: A Disputed Fortress in the Battle againstFrontiers in microbiology · 2017Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
Abstract
Sorting of luminal and membrane proteins into phagosomes is critical for the immune function of this organelle. However, little is known about the mechanisms that contribute to the spatiotemporal regulation of this process. Here, we investigated the role of the proneurotrophin receptor sortilin during phagosome maturation and mycobacterial killing. We show that this receptor is acquired by mycobacteria-containing phagosomes via interactions with the adaptor proteins AP-1 and GGAs. Interestingly, the phagosomal association of sortilin is critical for the delivery of acid sphingomyelinase (ASMase) and required for efficient phagosome maturation. Macrophages from Sort1(-/-) mice are less efficient in restricting the growth of Mycobacterium bovis BCG and M. tuberculosis. In vivo, Sort1(-/-) mice showed a substantial increase in cellular infiltration of neutrophils in their lungs and higher bacterial burden after infection with M. tuberculosis. Altogether, sortilin defines a pathway required for optimal intracellular mycobacteria control and lung inflammation in vivo.
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Registered trials
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