ArticleScientific reports2016
Population imaging at subcellular resolution supports specific and local inhibition by granule cells in the olfactory bulb.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Olfactory bulb granule cells: specialized to link coactive glomerular columns for percept generation and discrimination of odors.Cell and tissue research · 2021Article
- Activation of Granule Cell Interneurons by Two Divergent Local Circuit Pathways in the Rat Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Microglial depletion disrupts normal functional development of adult-born neurons in the olfactory bulb.eLife · 2020Article
- Local Postsynaptic Signaling on Slow Time Scales in Reciprocal Olfactory Bulb Granule Cell Spines Matches Asynchronous Release.Frontiers in synaptic neuroscience · 2020Article
- Improved Separation of Odor Responses in Granule Cells of the Olfactory Bulb During Odor Discrimination Learning.Frontiers in cellular neuroscience · 2020Article
- Axonal sodium channel NaV1.2 drives granule cell dendritic GABA release and rapid odor discrimination.PLoS biology · 2018Article
- Calcium-activated chloride channels clamp odor-evoked spike activity in olfactory receptor neurons.Scientific reports · 2018Article
- POU6f1 Mediates Neuropeptide-Dependent Plasticity in the Adult Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Article
- Spatial Structure of Synchronized Inhibition in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Inhibitory circuits of the mammalian main olfactory bulb.Journal of neurophysiology · 2017Review
- Respiration Gates Sensory Input Responses in the Mitral Cell Layer of the Olfactory Bulb.PloS one · 2016Article
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2 authors.
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Abstract
Information processing in early sensory regions is modulated by a diverse range of inhibitory interneurons. We sought to elucidate the role of olfactory bulb interneurons called granule cells (GCs) in odor processing by imaging the activity of hundreds of these cells simultaneously in mice. Odor responses in GCs were temporally diverse and spatially disperse, with some degree of non-random, modular organization. The overall sparseness of activation of GCs was highly correlated with the extent of glomerular activation by odor stimuli. Increasing concentrations of single odorants led to proportionately larger population activity, but some individual GCs had non-monotonic relations to concentration due to local inhibitory interactions. Individual dendritic segments could sometimes respond independently to odors, revealing their capacity for compartmentalized signaling in vivo. Collectively, the response properties of GCs point to their role in specific and local processing, rather than global operations such as response normalization proposed for other interneurons.
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