ArticleThe British journal of psychiatry : the journal of mental science2016
Increased mortality among people with anxiety disorders: total population study.
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Article in The British journal of psychiatry : the journal of mental science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 5 of them syntheses that pooled it.
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80citing papers in PubMed, 5 pooled it
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Who cites it
80 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Brain Aging in Specific Phobia: An ENIGMA-Anxiety Mega-Analysis.Human brain mapping · 2026Pooled it
- Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.Nature genetics · 2026Pooled it
- The association of statin use with the risk of anxiety: a systematic review and meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Lifetime posttraumatic stress disorder as a predictor of mortality: a systematic review and meta-analysis.BMC psychiatry · 2023Pooled it
- Global, regional and national burden of anxiety disorders from 1990 to 2019: results from the Global Burden of Disease Study 2019.Epidemiology and psychiatric sciences · 2021Pooled it
- Effect of mindfulness yoga on anxiety and depression in early breast cancer patients received adjuvant chemotherapy: a randomized clinical trial.Journal of cancer research and clinical oncology · 2022Trial
- Benefits from one session of deep and slow breathing on vagal tone and anxiety in young and older adults.Scientific reports · 2021Trial
- Trial
- Brain Ageing in Social Anxiety Disorder: An ENIGMA-Anxiety Mega-Analysis Across 26 International Cohorts.medRxiv : the preprint server for health sciences · 2026Article
- Risk of all-cause and cause-specific mortality, and suicide attempt in people with anxiety and stress-related disorders: a systematic review, meta-analysis and meta-regression analysis of 165 studies.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Methylome-wide association study in blood suggests cell type-specific relationships between DNA methylation and lifetime anxiety.Nature communications · 2026Article
- All-Cause and Cause-Specific Mortality in Patients With Bipolar II Disorder.JAMA network open · 2026Observational
- All-cause and cause-specific mortality in social anxiety disorder: a matched cohort and sibling cohort study.Epidemiology and psychiatric sciences · 2026Article
- Safety, Sedative, and Anxiolytic Evaluation of MECS Hard Capsules Using In Silico and In Vivo Approaches.ACS omega · 2026Article
- Post-traumatic stress disorder and risk of all-cause and cause-specific mortality: a nationwide population and sibling-controlled cohort study in Taiwan.Epidemiology and psychiatric sciences · 2026Article
- Contribution of social determinants to symptoms of generalized anxiety disorder.PLOS mental health · 2026Article
- Mortality among transgender persons: a Taiwan matched-population and sibling-comparison cohort study.The Lancet regional health. Western Pacific · 2025Article
- All-cause and cause-specific mortality in people with depression: a large-scale systematic review and meta-analysis of relative risk and aggravating or attenuating factors, including antidepressant treatment.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Experimental study on cannabis use and affect: Effects on reactivity to and recovery from negative stimuli.Journal of psychopathology and clinical science · 2025Article
- Association between physical activity and risk of anxiety: a dose-response meta-analysis of 11 international cohorts.EClinicalMedicine · 2025Article
20 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Sandra M MeierSandra M. Meier, PhD, National Centre for Register-Based Research, Aarhus University, Aarhus, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, and Mental Health Centre for Child and Adolescent Psychiatry, Copenhagen Region, Denmark; Manuel Mattheisen, MD, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, and Department of Biomedicine, Aarhus University, Aarhus, Denmark; Ole Mors, PhD, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, and Research Department P, Aarhus University Hospital, Risskov, Denmark; Preben B. Mortensen, DrMedSc, National Centre for Register-Based Research, Aarhus University, Aarhus, and The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Thomas M. Laursen, PhD, National Centre for Register-Based Research, Aarhus University, Aarhus, and The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Brenda W. Penninx, PhD, Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands smeier@econ.au.dk.
Manuel MattheisenSandra M. Meier, PhD, National Centre for Register-Based Research, Aarhus University, Aarhus, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, and Mental Health Centre for Child and Adolescent Psychiatry, Copenhagen Region, Denmark; Manuel Mattheisen, MD, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, and Department of Biomedicine, Aarhus University, Aarhus, Denmark; Ole Mors, PhD, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, and Research Department P, Aarhus University Hospital, Risskov, Denmark; Preben B. Mortensen, DrMedSc, National Centre for Register-Based Research, Aarhus University, Aarhus, and The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Thomas M. Laursen, PhD, National Centre for Register-Based Research, Aarhus University, Aarhus, and The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Brenda W. Penninx, PhD, Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands.
Ole MorsSandra M. Meier, PhD, National Centre for Register-Based Research, Aarhus University, Aarhus, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, and Mental Health Centre for Child and Adolescent Psychiatry, Copenhagen Region, Denmark; Manuel Mattheisen, MD, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, and Department of Biomedicine, Aarhus University, Aarhus, Denmark; Ole Mors, PhD, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, and Research Department P, Aarhus University Hospital, Risskov, Denmark; Preben B. Mortensen, DrMedSc, National Centre for Register-Based Research, Aarhus University, Aarhus, and The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Thomas M. Laursen, PhD, National Centre for Register-Based Research, Aarhus University, Aarhus, and The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Brenda W. Penninx, PhD, Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands.
Preben B MortensenSandra M. Meier, PhD, National Centre for Register-Based Research, Aarhus University, Aarhus, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, and Mental Health Centre for Child and Adolescent Psychiatry, Copenhagen Region, Denmark; Manuel Mattheisen, MD, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, and Department of Biomedicine, Aarhus University, Aarhus, Denmark; Ole Mors, PhD, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, and Research Department P, Aarhus University Hospital, Risskov, Denmark; Preben B. Mortensen, DrMedSc, National Centre for Register-Based Research, Aarhus University, Aarhus, and The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Thomas M. Laursen, PhD, National Centre for Register-Based Research, Aarhus University, Aarhus, and The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Brenda W. Penninx, PhD, Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands.
Thomas M LaursenSandra M. Meier, PhD, National Centre for Register-Based Research, Aarhus University, Aarhus, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, and Mental Health Centre for Child and Adolescent Psychiatry, Copenhagen Region, Denmark; Manuel Mattheisen, MD, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, and Department of Biomedicine, Aarhus University, Aarhus, Denmark; Ole Mors, PhD, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, and Research Department P, Aarhus University Hospital, Risskov, Denmark; Preben B. Mortensen, DrMedSc, National Centre for Register-Based Research, Aarhus University, Aarhus, and The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Thomas M. Laursen, PhD, National Centre for Register-Based Research, Aarhus University, Aarhus, and The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Brenda W. Penninx, PhD, Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands.
Brenda W PenninxSandra M. Meier, PhD, National Centre for Register-Based Research, Aarhus University, Aarhus, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, and Mental Health Centre for Child and Adolescent Psychiatry, Copenhagen Region, Denmark; Manuel Mattheisen, MD, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, and Department of Biomedicine, Aarhus University, Aarhus, Denmark; Ole Mors, PhD, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, and Research Department P, Aarhus University Hospital, Risskov, Denmark; Preben B. Mortensen, DrMedSc, National Centre for Register-Based Research, Aarhus University, Aarhus, and The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Thomas M. Laursen, PhD, National Centre for Register-Based Research, Aarhus University, Aarhus, and The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark; Brenda W. Penninx, PhD, Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands.
Funding
Genetic & Environmental Predictors of Tourette Syndrome & OCD in DenmarkR01MH105500 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CROWLEY, JAMES JOSEPH · 2015 to 2019
$3.0MNIMH NIH HHS R01 MH105500
Abstract
backgroundAnxiety disorders and depression are the most common mental disorders worldwide and have a striking impact on global disease burden. Although depression has consistently been found to increase mortality; the role of anxiety disorders in predicting mortality risk is unclear.
aimsTo assess mortality risk in people with anxiety disorders.
methodWe used nationwide Danish register data to conduct a prospective cohort study with over 30 million person-years of follow-up.
resultsIn total, 1066 (2.1%) people with anxiety disorders died during an average follow-up of 9.7 years. The risk of death by natural and unnatural causes was significantly higher among individuals with anxiety disorders (natural mortality rate ratio (MRR) = 1.39, 95% CI 1.28-1.51; unnatural MRR = 2.46, 95% CI 2.20-2.73) compared with the general population. Of those who died from unnatural causes, 16.5% had comorbid diagnoses of depression (MRR = 11.72, 95% CI 10.11-13.51).
conclusionsAnxiety disorders significantly increased mortality risk. Comorbidity of anxiety disorders and depression played an important part in the increased mortality.
Indexed as
AdultAnxiety DisordersCase-Control StudiesCause of DeathComorbidityDenmarkDepressionFemaleHumansMaleMiddle AgedRegistriesYoung Adult
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