ArticleRespiratory research2016
Micron-sized and submicron-sized aerosol deposition in a new ex vivo preclinical model.
Article in Respiratory research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- In vitro characterisation of fluticasone propionate and ciclesonide delivered with and without valved holding chambers using cascade impaction and an adult simulated breathing profile.BMJ open respiratory research · 2026Article
- Impact of gas humidification and nebulizer position under invasive ventilation: preclinical comparative study of regional aerosol deposition.Scientific reports · 2023Article
- Indoor air pollution effects on pediatric asthma are submicron aerosol particle-dependent.European journal of pediatrics · 2022Article
- In Vitro Evaluation of Nasal Aerosol Depositions: An Insight for Direct Nose to Brain Drug Delivery.Pharmaceutics · 2021Review
- Letter to editor.European journal of nuclear medicine and molecular imaging · 2020Article
- Nebulised Gadolinium-Based Nanoparticles for a Multimodal Approach: Quantitative and Qualitative Lung Distribution Using Magnetic Resonance and Scintigraphy Imaging in Isolated Ventilated Porcine Lungs.International journal of nanomedicine · 2020Article
- Development of an ex vivo preclinical respiratory model of idiopathic pulmonary fibrosis for aerosol regional studies.Scientific reports · 2019Article
- Aerosol delivery during invasive mechanical ventilation: development of a preclinical ex vivo respiratory model for aerosol regional deposition.Scientific reports · 2019Article
- In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica.European radiology experimental · 2019Article
- Development of an ex vivo respiratory pediatric model of bronchopulmonary dysplasia for aerosol deposition studies.Scientific reports · 2019Article
- Experimental human-like model to assess the part of viable Legionella reaching the thoracic region after nebulization.PloS one · 2017Article
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8 authors.
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Abstract
backgroundThe knowledge of where particles deposit in the respiratory tract is crucial for understanding the health effects associated with inhaled drug particles.
methodAn ex vivo study was conducted to assess regional deposition patterns (thoracic vs. extrathoracic) of radioactive polydisperse aerosols with different size ranges [0.15 μm-0.5 μm], [0.25 μm-1 μm] and [1 μm-9 μm]. SPECT/CT analyses were performed complementary in order to assess more precisely the regional deposition of aerosols within the pulmonary tract. Experiments were set using an original respiratory tract model composed of a human plastinated head connected to an ex vivo porcine pulmonary tract. The model was ventilated by passive expansion, simulating pleural depressions. Aerosol was administered during nasal breathing.
resultsPlanar scintigraphies allowed to calculate the deposited aerosol fractions for particles in the three size ranges from sub-micron to micron The deposited fractions obtained, for thoracic vs. extra-thoracic regions respectively, were 89 ± 4 % vs. 11 ± 4 % for [0.15 μm-0.5 μm], 78 ± 5 % vs. 22 ± 5 % for [0.25 μm-1 μm] and 35 ± 11 % vs.65 ± 11 % for [1 μm-9 μm].
conclusionResults obtained with this new ex vivo respiratory tract model are in good agreement with the in vivo data obtained in studies with baboons and humans.
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