ArticleBMC psychiatry2016
Cortical functional activity in patients with generalized anxiety disorder.
Article in BMC psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The relationship between emotional regulation and hemispheric lateralization in depression: a systematic review and a meta-analysis.Translational psychiatry · 2022Pooled it
- A novel deep learning model for objective quantification of generalized anxiety disorder severity using EEG functional connectivity.Frontiers in psychiatry · 2026Article
- Integrating EEG and Ensemble Learning for Accurate Grading and Quantification of Generalized Anxiety Disorder: A Novel Diagnostic Approach.Diagnostics (Basel, Switzerland) · 2024Article
- Baseline symptom severity and efficacy of Silexan in patients with anxiety disorders: A symptom-based, patient-level analysis of randomized, placebo-controlled trials.European psychiatry : the journal of the Association of European Psychiatrists · 2024Review
- Prolonged Disease Course Leads to Impaired Brain Function in Anxiety Disorder: A Resting State EEG Study.Neuropsychiatric disease and treatment · 2024Article
- Altered Functional Brain Network Structure between Patients with High and Low Generalized Anxiety Disorder.Diagnostics (Basel, Switzerland) · 2023Article
- Enhancing generalized anxiety disorder diagnosis precision: MSTCNN model utilizing high-frequency EEG signals.Frontiers in psychiatry · 2023Article
- Brain entropy, fractal dimensions and predictability: A review of complexity measures for EEG in healthy and neuropsychiatric populations.The European journal of neuroscience · 2022Review
- Aberrated Multidimensional EEG Characteristics in Patients with Generalized Anxiety Disorder: A Machine-Learning Based Analysis Framework.Sensors (Basel, Switzerland) · 2022Article
- Quantitative Electroencephalography (QEEG) as an Innovative Diagnostic Tool in Mental Disorders.International journal of environmental research and public health · 2022Article
- Difference analysis of multidimensional electroencephalogram characteristics between young and old patients with generalized anxiety disorder.Frontiers in human neuroscience · 2022Article
- Higuchi's fractal dimension, but not frontal or posterior alpha asymmetry, predicts PID-5 anxiousness more than depressivity.Scientific reports · 2019Article
- High Sensitivity Mapping of Cortical Dopamine D2 Receptor Expressing Neurons.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Acute Chemogenetic Activation of CamKIIα-Positive Forebrain Excitatory Neurons Regulates Anxiety-Like Behaviour in Mice.Frontiers in behavioral neuroscience · 2019Article
- Modified Suanzaorentang Had the Treatment Effect for Generalized Anxiety Disorder for the First 4 Weeks of Paroxetine Medication: A Pragmatic Randomized Controlled Study.Evidence-based complementary and alternative medicine : eCAM · 2017Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe neurological correlates of Generalised Anxiety Disorder (GAD) are not well known, however there is evidence of cortical dysregulation in patients with GAD. The aim of the study was to examine cortical functional activity in different cerebral regions in patients with GAD using electroencephalogram (EEG) nonlinear analysis to evaluate its contribution of anxiety severity.
methodsThe cohorts consisted of 64 patients diagnosed with GAD as classified by the Structured Clinical Interview for the Diagnostic and Statistical Manual of the American Psychiatric Association-IV-TR. Anxiety severity was assessed using the Hamilton Rating Scale for Anxiety (HAMA) severity score, with 7 ≤ scores ≤ 17 indicating mild anxiety as A group (n = 31) and 18 and above indicating moderate-severe anxiety as B group (n = 33). Participants with clinical levels of depression symptoms were excluded. A healthy control group comprising 30 participants was matched for age and gender. Closed eyes EEGs were conducted, and between-group differences on non-linear parameter Correlation Dimension (D2) were analyzed. The association of D2 value with HAMA scores was analyzed using multiple linear stepwise regression.
resultsCompared with the control group, D2 values were increased in anxiety groups (P < .05). For those with mild anxiety, this difference occurred in the left prefrontal regions (P < .05). For those with moderate-severe anxiety, significantly greater D2 values were observed in all of the cerebral regions, especially in the left cerebral regions and right temporal lobe (P < .01). When compared with those with mild anxiety, D2 values were significantly greater for those with moderate-severe anxiety in the right temporal lobe and all left cerebral regions except for left occipital lobe (P < .05). A positive correlation was observed between D2 values and moderate-severe anxiety HAMA scores.
conclusionsThe increased D2 values were found in the majority of cerebral regions in GAD patients, especially in the left cerebral regions and the right temporal lobe. The increased GAD severity positively correlates to the D2 values in a larger number of cerebral regions. This analysis method can potentially be used as a complementary tool to examine dysfunctional cortical activity in GAD.
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