Evidence map›Paper›PMID 27388462›Full record

SynthesisEuropean journal of nutrition2017

Coffee, tea and caffeine intake and the risk of non-melanoma skin cancer: a review of the literature and meta-analysis.

Saverio Caini, Maria Sofia Cattaruzza, Benedetta Bendinelli, Giulio Tosti, Giovanna Masala, Patrizia Gnagnarella, Melania Assedi, Ignazio Stanganelli, Domenico Palli, Sara Gandini

Erratum issuedAbstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in European journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.

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  16. Daily Lifestyle and Cutaneous Malignancies.International journal of molecular sciences · 2021
    Review
  17. Article
  18. A Decade of Research on Coffee as an Anticarcinogenic Beverage.Oxidative medicine and cellular longevity · 2021
    Review
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  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Saverio CainiCancer Risk Factors and Lifestyle Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Via delle Oblate 2, 50139, Florence, Italy. s.caini@ispo.toscana.it.
Maria Sofia CattaruzzaDepartment of Public Health and Infectious Diseases, Faculty of Medicine, Policlinico Umberto I, "Sapienza" University, Rome, Italy.
Benedetta BendinelliCancer Risk Factors and Lifestyle Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Via delle Oblate 2, 50139, Florence, Italy.
Giulio TostiDivision of Dermatoncological Surgery, European Institute of Oncology, Milan, Italy.
Giovanna MasalaCancer Risk Factors and Lifestyle Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Via delle Oblate 2, 50139, Florence, Italy.
Patrizia GnagnarellaDivision of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy.
Melania AssediCancer Risk Factors and Lifestyle Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Via delle Oblate 2, 50139, Florence, Italy.
Ignazio StanganelliSkin Cancer Unit, Scientific Institute of Romagna for the Study and Treatment of Cancer, IRCSS, IRST, Meldola, Italy.
Domenico PalliCancer Risk Factors and Lifestyle Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Via delle Oblate 2, 50139, Florence, Italy.
Sara GandiniDivision of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy.
Piedmont Reference Center for Epidemiology and Cancer Prevention · ITEuropean Institute of Oncology · ITIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori · ITPoliclinico Umberto I · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLaboratory studies suggested that caffeine and other nutrients contained in coffee and tea may protect against non-melanoma skin cancer (NMSC). However, epidemiological studies conducted so far have produced conflicting results.

methodsWe performed a literature review and meta-analysis of observational studies published until February 2016 that investigated the association between coffee and tea intake and NMSC risk. We calculated summary relative risk (SRR) and corresponding 95 % confidence intervals (95 % CI) by using random effects with maximum likelihood estimation.

resultsOverall, 37,627 NMSC cases from 13 papers were available for analysis. Intake of caffeinated coffee was inversely associated with NMSC risk (SRR for those in the highest vs. lowest category of intake: 0.82, 95 % CI 0.75-0.89, I

conclusionsCoffee intake appears to exert a moderate protective effect against BCC development, probably through the biological effect of caffeine. However, the observational nature of studies included, subject to bias and confounding, suggests taking with caution these results that should be verified in randomized clinical trials.

Indexed as

Basal Cell CarcinomaCaffeineCoffeeHumansObservational Studies as TopicRisk FactorsSkin NeoplasmsTeaCaffeineCoffeeTeaCaffeineCoffeeMeta-analysisNon-melanoma skin cancerTea

Identifiers

PMID27388462
OpenAlexW2473560036

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.