ArticleScientific reports2016
Molecular insights into chronotype and time-of-day effects on decision-making.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 53 citations in OpenAlex.
- The Influence of Time of Day on Critical Swimming Speed in Chronotype-Screened (Neither-Type) Well-Trained Male Swimmers.Life (Basel, Switzerland) · 2026Article
- Influence of Chronotype on Cycling Performance in Simulated 20-km Time Trials-A Pilot Study.Journal of sleep research · 2026Article
- A common alteration in effort-based decision-making in apathy, anhedonia, and late circadian rhythm.eLife · 2025Article
- Sex- and Substance-Specific Associations of Circadian-Related Genes with Addiction in the UK Biobank Cohort Implicate Neuroplasticity Pathways.Brain sciences · 2024Article
- Time of Day and Sleep Deprivation Effects on Risky Decision Making.Clocks & sleep · 2024Article
- Ethological computational psychiatry: Challenges and opportunities.Current opinion in neurobiology · 2024Review
- Risk taking for potential losses but not gains increases with time of day.Scientific reports · 2023Article
- Hair Follicles as a Critical Model for Monitoring the Circadian Clock.International journal of molecular sciences · 2023Review
- Machine learning and expression analyses reveal circadian clock features predictive of anxiety.Scientific reports · 2022Article
- Diurnal Preference and Grey Matter Volume in a Large Population of Older Adults: Data from the UK Biobank.Journal of circadian rhythms · 2020Article
- Ideal Time of Day for Risky Decision Making: Evidence from the Balloon Analogue Risk Task.Nature and science of sleep · 2020Article
- Article
- Circadian Effects on Performance and Effort in Collegiate Swimmers.Journal of circadian rhythms · 2018Article
- Dad's Snoring May Have Left Molecular Scars in Your DNA: the Emerging Role of Epigenetics in Sleep Disorders.Molecular neurobiology · 2018Review
- Biological Clocks and Rhythms of Anger and Aggression.Frontiers in behavioral neuroscience · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent reports highlight that human decision-making is influenced by the time of day and whether one is a morning or evening person (i.e., chronotype). Here, we test whether these behavioral effects are associated with endogenous biological rhythms. We asked participants to complete two well-established decision-making tasks in the morning or evening: the matrix task (an ethical decision task) and the balloon analog risk task (BART; a risk-taking task), and we measured their chronotype in two ways. First, participants completed a self-report measure, the Horne-Östberg Morningness-Eveningness Questionnaire (MEQ). Second, we measured the expression of two circadian clock-regulated genes-Per3 and Nr1d2-from peripheral clock cells in participants' hair follicle samples. Using a cosinor model, we estimated the phase of the peripheral clock and assigned RNA chronotypes to participants with advanced (larks) or delayed (owls) phases. The behavioral data were analyzed independently for self-reported (MEQ) and RNA-based chronotypes. We find that significant chronotype and/or time-of-day effects between larks and owls in decision-making tasks occur only in RNA-based chronotypes. Our results provide evidence that time-of-day effects on decision-making can be explained by phase differences in oscillating clock genes and suggest that variation in the molecular clockwork may influence inter-individual differences in decision-making behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.