ArticleClinical research in cardiology : official journal of the German Cardiac Society2017
T1 and T2 mapping cardiovascular magnetic resonance imaging techniques reveal unapparent myocardial injury in patients with myocarditis.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Obstructive sleep apnea increases the risk of cardiovascular damage: a systematic review and meta-analysis of imaging studies.Systematic reviews · 2021Pooled it
- Cardiovascular magnetic resonance native TJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Pooled it
- Diagnostic and prognostic value of cardiac magnetic resonance in acute myocarditis: a systematic review and meta-analysis.The international journal of cardiovascular imaging · 2019Pooled it
- Native TJournal of magnetic resonance imaging : JMRI · 2018Pooled it
- Left ventricular ejection fraction and presence of myocardial necrosis assessed by cardiac magnetic resonance imaging correctly risk stratify patients with stable coronary artery disease: a multi-center all-comers trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Trial
- Cardiac MRI monitoring in acute myocarditis: predicting outcomes through serial imaging.European radiology · 2026Article
- Cardiac involvement in established idiopathic inflammatory myopathy assessed by cardiac magnetic resonance mapping.Clinical rheumatology · 2025Article
- Review
- Cardiovascular magnetic resonance parametric mapping in the risk stratification of patients affected by chronic myocarditis.European radiology · 2025Article
- Cardiac toxicity and intervention strategies during thoracic cancer radiotherapy.Frontiers in oncology · 2025Review
- Impact of cannabidiol on myocardial recovery in patients with acute myocarditis: Rationale & design of the ARCHER trial.ESC heart failure · 2024Article
- Clinical Applications of Cardiac Magnetic Resonance Parametric Mapping.Diagnostics (Basel, Switzerland) · 2024Review
- Imaging Assessment of Radiation Therapy-Related Normal Tissue Injury in Children: A PENTEC Visionary Statement.International journal of radiation oncology, biology, physics · 2024Review
- Absence of cardiac impairment in patients after severe acute respiratory syndrome coronavirus type 2 infection: A long-term follow-up study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024Article
- Differentiation of acute non-ST elevation myocardial infarction and acute infarct-like myocarditis by visual pattern analysis: a head-to-head comparison of different cardiac MR techniques.European radiology · 2023Article
- Heart Involvement in Systemic Sclerosis: the Role of Magnetic Resonance Imaging.Clinical reviews in allergy & immunology · 2023Review
- Cardiac Magnetic Resonance Fingerprinting: Potential Clinical Applications.Current cardiology reports · 2023Review
- Evolution of myocardial oedema and fibrosis in HIV infected persons after the initiation of antiretroviral therapy: a prospective cardiovascular magnetic resonance study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022Article
- Cardiac involvement in patients recovering from Delta Variant of COVID-19: a prospective multi-parametric MRI study.ESC heart failure · 2022Article
- Characteristics and Prognostic Relevance of Ventricular Arrhythmia in Patients with Myocarditis.Journal of cardiovascular development and disease · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study evaluated the ability of T1 and T2 mapping cardiovascular magnetic resonance (CMR) to detect myocardial injury in apparently normal myocardium of patients with myocarditis. MATERIALS AND
methodsWe included 20 patients with "infarct-like" acute myocarditis who had typical focal myocardial lesions on late gadolinium enhancement (LGE) images as well as 20 healthy controls. The CMR protocol consisted of a standard myocarditis protocol which was combined with T1 (modified Look-Locker inversion recovery (MOLLI) with a 3(3)5 scheme and T2 mapping (hybrid gradient- and spin-echo multi-echo sequence, GraSE). First, LGE images were used to depict focal myocardial injury and apparently normal, remote myocardium. Second, native T1, T2 and ECV values were obtained in focal lesions but also in apparently normal myocardium. Third, native T1, T2 and ECV values ≥2 standard deviations above reference values obtained in healthy volunteers were used to quantify myocardial injury in patients with myocarditis.
resultsApparently normal myocardium had significantly higher median native T1 [1095 (1055-1148) ms] and ECV [34 (32-35) %] values compared to reference values from healthy volunteers, which were 1051 (1021-1064) ms (p < 0.01) and 26 (24-27) % (p < 0.0001). Furthermore, a nonsignificant increase in median myocardial T2 was detected in apparently normal myocardium of patients with myocarditis compared to healthy volunteers [59 (55-65) vs. 56 (54-60) ms; p = 0.18]. Consequently, the amount of myocardial injury was significantly larger on native T1 [48 (32-56) %; p < 0.01] and ECV maps [58 (50-66) %; p < 0.01] compared to LGE [14 (9-20) %].
conclusionsNative T1 and ECV maps reveal hidden myocardial injury in normal appearing myocardium of patients with myocarditis. The amount of myocardial injury in myocarditis was underestimated by conventional LGE imaging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.