Evidence map›Paper›PMID 27388330›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016

Genotype-Dependent Effects of COMT Inhibition on Cognitive Function in a Highly Specific, Novel Mouse Model of Altered COMT Activity.

Chris Barkus, Clio Korn, Katharina Stumpenhorst, Linda M Laatikainen, Dominic Ballard, Sheena Lee, Trevor Sharp, Paul J Harrison, David M Bannerman, Daniel R Weinberger and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Effects of COMT genotype and tolcapone on lapses of sustained attention after sleep deprivation in healthy young men.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Effort-related decision making in humanized COMT mice: Effects of ValPharmacology, biochemistry, and behavior · 2020
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Chris BarkusDepartment of Psychiatry, University of Oxford, Oxford, UK.
Clio KornDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID 0000-0001-6328-6876
Katharina StumpenhorstDepartment of Psychiatry, University of Oxford, Oxford, UK.
Linda M LaatikainenDepartment of Psychiatry, University of Oxford, Oxford, UK.
Dominic BallardMedical School, University of Oxford, Oxford, UK.
Sheena LeeDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Trevor SharpDepartment of Pharmacology, University of Oxford, Oxford, UK.
Paul J HarrisonDepartment of Psychiatry, University of Oxford, Oxford, UK.
David M BannermanDepartment of Experimental Psychology, University of Oxford, Oxford, UK.
Daniel R WeinbergerLieber Institute for Brain Development, Johns Hopkins University, Baltimore, MD, USA.
Jingshan ChenNational Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Elizabeth M TunbridgeDepartment of Psychiatry, University of Oxford, Oxford, UK.
University of Oxford · GBOxford Health NHS Foundation Trust · GBJohns Hopkins University · USNational Institutes of Health · US

Funding

Medical Research Council G0700983Wellcome Trust 087736
6 · The paper itself

Abstract

Catechol-O-methyltransferase (COMT) modulates dopamine levels in the prefrontal cortex. The human gene contains a polymorphism (Val

Indexed as

Disease Models, AnimalAnalysis of VarianceAnimalsBenzophenonesBrainCatechol O-MethyltransferaseCatechol O-Methyltransferase InhibitorsChoice BehaviorCognition DisordersExploratory BehaviorGenotypeMaze LearningMethionineMiceMice, TransgenicNitrophenolsBenzophenonesCatechol O-MethyltransferaseCatechol O-Methyltransferase InhibitorsCOMT protein, mouseMethionineNitrophenolsTolcaponeValine

Identifiers

PMID27388330
PMCPMC5101554
OpenAlexW2463085872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.