Evidence map›Paper›PMID 27388144›Full record

ArticleJournal of autoimmunity2016

A Child's HLA-DRB1 genotype increases maternal risk of systemic lupus erythematosus.

Giovanna I Cruz, Xiaorong Shao, Hong Quach, Kimberly A Ho, Kirsten Sterba, Janelle A Noble, Nikolaos A Patsopoulos, Michael P Busch, Darrell J Triulzi, Wendy S W Wong and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of autoimmunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Association ofChinese medical journal · 2018
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Autoimmunity in 2016.Clinical reviews in allergy & immunology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 2 countries.

Giovanna I CruzGenetic Epidemiology and Genomics Lab, Division of Epidemiology, School of Public Health, University of California Berkeley, 324 Stanley Hall, Berkeley, CA 94720-3220, USA. Electronic address: gcruz@berkeley.edu.
Xiaorong ShaoGenetic Epidemiology and Genomics Lab, Division of Epidemiology, School of Public Health, University of California Berkeley, 324 Stanley Hall, Berkeley, CA 94720-3220, USA. Electronic address: xshao@berkeley.edu.
Hong QuachGenetic Epidemiology and Genomics Lab, Division of Epidemiology, School of Public Health, University of California Berkeley, 324 Stanley Hall, Berkeley, CA 94720-3220, USA. Electronic address: hquach@berkeley.edu.
Kimberly A HoRosalind Russell/Ephraim P. Engleman Rheumatology Research Center, Department of Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94122, USA. Electronic address: ho.kimberly@gmail.com.
Kirsten SterbaRosalind Russell/Ephraim P. Engleman Rheumatology Research Center, Department of Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94122, USA. Electronic address: thesterbas@gmail.com.
Janelle A NobleChildren's Hospital Oakland Research Institute, 5700 M.L.K. Jr. Way, Oakland, CA 94609, USA. Electronic address: jnoble@chori.org.
Nikolaos A PatsopoulosDivision of Genetics, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA; Program in Translational Neuropsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham & Women's Hospital, 75 Francis Street, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, 415 Main Street, Cambridge, MA 02142, USA. Electronic address: npatsopoulos@rics.bwh.harvard.edu.
Michael P BuschBlood Systems Research Institute, 270 Masonic Avenue, San Francisco, CA 94118-4417, USA. Electronic address: mbusch@bloodsystems.org.
Darrell J TriulziInstitute for Transfusion Medicine, Department of Pathology, University of Pittsburgh, 3636 Blvd. of the Allies, Pittsburgh, PA 15213, USA. Electronic address: DTriulzi@itxm.org.
Wendy S W WongDivision of Medical Genomics, Inova Translational Medicine Institute, 8110 Gatehouse Road, Falls Church, VA 22042, USA. Electronic address: ShukwanWendy.Wong@inova.org.
Benjamin D SolomonDivision of Medical Genomics, Inova Translational Medicine Institute, 8110 Gatehouse Road, Falls Church, VA 22042, USA. Electronic address: Benjamin.Solomon@inova.org.
John E NiederhuberDivision of Medical Genomics, Inova Translational Medicine Institute, 8110 Gatehouse Road, Falls Church, VA 22042, USA. Electronic address: John.Niederhuber@inova.org.
Lindsey A CriswellRosalind Russell/Ephraim P. Engleman Rheumatology Research Center, Department of Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94122, USA. Electronic address: Lindsey.Criswell@ucsf.edu.
Lisa F BarcellosGenetic Epidemiology and Genomics Lab, Division of Epidemiology, School of Public Health, University of California Berkeley, 324 Stanley Hall, Berkeley, CA 94720-3220, USA; California Institute for Quantitative Biosciences (QB3), University of California Berkeley, 174 Stanley Hall, Berkeley, CA 94720-3220, USA. Electronic address: lbarcellos@berkeley.edu.
Inova Health System · USUniversity of California, Berkeley · USUniversity of California, San Francisco · USBlood Systems Research Institute · USBrigham and Women's Hospital · USChildren's Research Hospital · JPInstitute for Transfusion Medicine · USQB3 · US

Funding

ZD1839 FOR MALIGNANT ASTROCYTOMA OR GLIOBLASTOMA AND MENINGIOMAM01RR000079 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$26.0M
The Interplay of Sociodemographic and Genetic Factors in SLE Health DisparitiesP60AR053308 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KATZ, PATRICIA P · 2006 to 2016
$11.8M
Immunogenetic Studies of Autoimmune DiseaseR01AI059829 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARCELLOS, LISA F · 2004 to 2008
$1.9M
Mother-child genetic contributions to autoimmunityR21AI117879 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARCELLOS, LISA F · 2015 to 2016
$447k
Fetal-Maternal Histocompatibility and Autoimmune DiseaseF31AI116064 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI CRUZ, GIOVANNA · 2015 to 2016
$62k
NCRR NIH HHS M01 RR000079NIAID NIH HHS F31 AI116064NIAID NIH HHS R01 AI059829NIAID NIH HHS R21 AI117879NIAMS NIH HHS P60 AR053308
6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) disproportionately affects women of reproductive age. During pregnancy, women are exposed to various sources of fetal material possibly constituting a significant immunologic exposure relevant to the development of SLE. The objective of this study was to investigate whether having any children who carry DRB1 alleles associated with SLE increase the risk of maternal SLE. This case-control study is based on the University of California, San Francisco Mother-Child Immunogenetic Study and from studies at the Inova Translational Medicine Institute. Analyses were conducted using data for 1304 mothers (219 cases/1085 controls) and their respective 1664 children. We selected alleles based on their known association with risk of SLE (DRB1*03:01, *15:01, or *08:01) or Epstein-Barr virus (EBV) glycoproteins (*04:01) due to the established EBV association with SLE risk. We used logistic regression models to estimate odds ratios (OR) and 95% confidence intervals (CI) for each allele of interest, taking into account maternal genotype and number of live births. We found an increase in risk of maternal SLE associated with exposure to children who inherited DRB1*04:01 from their father (OR 1.9; 95% CI, 1.1-3.2), among *04:01 allele-negative mothers. Increased risk was only present among mothers who were positive for one or more SLE risk-associated alleles (*03:01, *15:01 and/or *08:01). We did not find increased risk of maternal SLE associated with any other tested allele. These findings support the hypothesis that a child's alleles inherited from the father influence a mother's subsequent risk of SLE.

Indexed as

GenotypeAdultAllelesAutoantibodiesCase-Control StudiesChildFemaleGenetic Predisposition to DiseaseHLA-DRB1 ChainsHumansLupus Erythematosus, SystemicMaternal-Fetal ExchangeMiddle AgedOdds RatioPregnancyAutoantibodiesHLA-DRB1 ChainsGenetic epidemiologyHuman leukocyte antigen genesPregnancySystemic lupus erythematosus

Identifiers

PMID27388144
PMCPMC5079818
OpenAlexW2466646123

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.