Evidence map›Paper›PMID 27387922›Full record

Trial reportTheoretical biology & medical modelling2016

Feed-forward neural network model for hunger and satiety related VAS score prediction.

Shaji Krishnan, Henk F J Hendriks, Merete L Hartvigsen, Albert A de Graaf

Abstract readClinical Trial
In one paragraph

Trial report in Theoretical biology & medical modelling, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shaji KrishnanRisk Analysis for Products In Development, TNO, Utrechtseweg 48, P.O. Box 360, Zeist, 3700 AJ, The Netherlands. shaji.krishnan@tno.nl.
Henk F J HendriksTop Institute Food and Nutrition, Nieuwe Kanaal 9A, Wageningen, 6709 PA, The Netherlands.
Merete L HartvigsenDepartment of Endocrinology and Internal Medicine, Aarhus University, Tage-Hansens Gade 2, Aarhus C, DK-8000, Denmark.
Albert A de GraafRisk Analysis for Products In Development, TNO, Utrechtseweg 48, P.O. Box 360, Zeist, 3700 AJ, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn artificial neural network approach was chosen to model the outcome of the complex signaling pathways in the gastro-intestinal tract and other peripheral organs that eventually produce the satiety feeling in the brain upon feeding.

methodsA multilayer feed-forward neural network was trained with sets of experimental data relating concentration-time courses of plasma satiety hormones to Visual Analog Scales (VAS) scores. The network successfully predicted VAS responses from sets of satiety hormone data obtained in experiments using different food compositions.

resultsThe correlation coefficients for the predicted VAS responses for test sets having i) a full set of three satiety hormones, ii) a set of only two satiety hormones, and iii) a set of only one satiety hormone were 0.96, 0.96, and 0.89, respectively. The predicted VAS responses discriminated the satiety effects of high satiating food types from less satiating food types both in orally fed and ileal infused forms.

conclusionsFrom this application of artificial neural networks, one may conclude that neural network models are very suitable to describe situations where behavior is complex and incompletely understood. However, training data sets that fit the experimental conditions need to be available.

Indexed as

Models, BiologicalNeural Networks, ComputerVisual Analog ScaleAdministration, OralCholecystokininDatabases as TopicHumansHungerIleumPeptide YYSatiationStomachCholecystokininPeptide YYModelingSatietyVisual analog scales (VAS)

Identifiers

PMID27387922
PMCPMC4936290

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.