ArticleDevelopment (Cambridge, England)2016
Lizard tail skeletal regeneration combines aspects of fracture healing and blastema-based regeneration.
Article in Development (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 74 citations in OpenAlex.
- The tiger salamander as a promising alternative model organism to the axolotl for fracture healing and regenerative biology research.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- Simulation of adult limb regeneration with lizard tail spinal cord implants reveals distinct roles of radial glia and microglia populations.Research square · 2025Article
- Tokay gecko tail regeneration involves temporally collinear expression of HOXC genes and early expression of satellite cell markers.BMC biology · 2025Article
- SlugAtlas, a histological and 3D online resource of the land slugs Deroceras laeve and Ambigolimax valentianus.PloS one · 2024Article
- Single-cell analysis of lizard blastema fibroblasts reveals phagocyte-dependent activation of Hedgehog-responsive chondrogenesis.Nature communications · 2023Article
- Altered developmental programs and oriented cell divisions lead to bulky bones during salamander limb regeneration.Nature communications · 2022Article
- A murine model of large-scale bone regeneration reveals a selective requirement for Sonic Hedgehog.NPJ Regenerative medicine · 2022Article
- On the horizon: Hedgehog signaling to heal broken bones.Bone research · 2022Review
- Lizard Blastema Organoid Model Recapitulates Regenerated Tail Chondrogenesis.Journal of developmental biology · 2022Article
- Introduction to the Study on Regeneration in Lizards as an Amniote Model of Organ Regeneration.Journal of developmental biology · 2021Article
- Introducing dorsoventral patterning in adult regenerating lizard tails with gene-edited embryonic neural stem cells.Nature communications · 2021Article
- Regeneration in Reptiles Generally and the New Zealand Tuatara in Particular as a Model to Analyse Organ Regrowth in Amniotes: A Review.Journal of developmental biology · 2021Review
- Evolutionary bedfellows: Reconstructing the ancestral state of autotomy and regeneration.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2021Article
- Review
- Article
- Anatomical and histological analyses reveal that tail repair is coupled with regrowth in wild-caught, juvenile American alligators (Alligator mississippiensis).Scientific reports · 2020Article
- Single Cell Sequencing Analysis of Lizard Phagocytic Cell Populations and Their Role in Tail Regeneration.Journal of immunology and regenerative medicine · 2020Article
- Immunodetection of ephrin receptors in the regenerating tail of the lizardZoological research · 2019Article
- Expression and role of HIF-1α and HIF-2α in tissue regeneration: a study of hypoxia in house gecko tail regeneration.Organogenesis · 2019Article
- Differences in neural stem cell identity and differentiation capacity drive divergent regenerative outcomes in lizards and salamanders.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Lizards are amniotes with the remarkable ability to regenerate amputated tails. The early regenerated lizard tail forms a blastema, and the regenerated skeleton consists of a cartilage tube (CT) surrounding the regenerated spinal cord. The proximal, but not distal, CT undergoes hypertrophy and ossifies. We hypothesized that differences in cell sources and signaling account for divergent cartilage development between proximal and distal CT regions. Exogenous spinal cord implants induced ectopic CT formation in lizard (Anolis carolinensis) blastemas. Regenerated spinal cords expressed Shh, and cyclopamine inhibited CT induction. Blastemas containing vertebrae with intact spinal cords formed CTs with proximal hypertrophic regions and distal non-hypertrophic regions, whereas removal of spinal cords resulted in formation of proximal CT areas only. In fate-mapping studies, FITC-labeled vertebra periosteal cells were detected in proximal, but not distal, CT areas. Conversely, FITC-labeled blastema cells were restricted to distal CT regions. Proximal cartilage formation was inhibited by removal of periosteum and could be recapitulated in vitro by periosteal cells treated with Ihh and BMP-2. These findings suggest that proximal CTs are directly derived from vertebra periosteal cells in response to BMP and Ihh signaling, whereas distal CTs form from blastema cells in response to Shh signals from regenerated spinal cords.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.