ReviewReviews in endocrine & metabolic disorders2016
Artificial sweeteners and metabolic dysregulation: Lessons learned from agriculture and the laboratory.
Review in Reviews in endocrine & metabolic disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Differential associations of beverage consumption with diabetic retinopathy: a systematic review and dose-response meta-analysis of observational studies.Frontiers in medicine · 2026Pooled it
- Pooled it
- Hypotheses and evidence related to intense sweeteners and effects on appetite and body weight changes: A scoping review of reviews.PloS one · 2018Pooled it
- Trial
- Effects of a Carob-Pod-Derived Sweetener on Glucose Metabolism.Nutrients · 2018Trial
- Association of ultra-processed food consumption with all-cause and cause-specific mortality: population-based cohort study.Frontiers in nutrition · 2026Article
- Association of 37 markers of ultra-processing with all-cause mortality: a prospective cohort study in the UK Biobank.EClinicalMedicine · 2025Article
- Rebaudioside D and M, the next-generation sugar substitutes, do not exacerbate metabolic dysfunction in high-fat diet mice.Food chemistry: X · 2025Article
- Article
- Added flavors: potential contributors to body weight gain and obesity?BMC medicine · 2022Article
- Rationale and design of DRINK-T1D: A randomized clinical trial of effects of low-calorie sweetener restriction in children with type 1 diabetes.Contemporary clinical trials · 2021Article
- Perspective: Standards for Research and Reporting on Low-Energy ("Artificial") Sweeteners.Advances in nutrition (Bethesda, Md.) · 2020Article
- Preference of sweeteners among Saudi diabetes patients from a tertiary health care centre in Riyadh, Saudi Arabia.Saudi journal of biological sciences · 2020Article
- Metabolically healthy obese and metabolic syndrome of the lean: the importance of diet quality. Analysis of MAGNETIC cohort.Nutrition journal · 2020Article
- From biology to behavior: a cross-disciplinary seminar series surrounding added sugar and low-calorie sweetener consumption.Obesity science & practice · 2019Review
- Pathways and mechanisms linking dietary components to cardiometabolic disease: thinking beyond calories.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2018Review
- Diet and physical activity as possible mediators of the association between educational attainment and body mass index gain among Australian adults.International journal of public health · 2018Article
- Soft drinks consumption is associated with nonalcoholic fatty liver disease independent of metabolic syndrome in Chinese population.European journal of nutrition · 2018Article
- Stevia Nonsweetener Fraction Displays an Insulinotropic Effect Involving Neurotransmission in Pancreatic Islets.International journal of endocrinology · 2018Article
- Separating "good" from "bad" faecal dysbiosis - evidence from two cross-sectional studies.BMC obesity · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Escalating rates of obesity and public health messages to reduce excessive sugar intake have fuelled the consumption of artificial sweeteners in a wide range of products from breakfast cereals to snack foods and beverages. Artificial sweeteners impart a sweet taste without the associated energy and have been widely recommended by medical professionals since they are considered safe. However, associations observed in long-term prospective studies raise the concern that regular consumption of artificial sweeteners might actually contribute to development of metabolic derangements that lead to obesity, type 2 diabetes and cardiovascular disease. Obtaining mechanistic data on artificial sweetener use in humans in relation to metabolic dysfunction is difficult due to the long time frames over which dietary factors might exert their effects on health and the large number of confounding variables that need to be considered. Thus, mechanistic data from animal models can be highly useful because they permit greater experimental control. Results from animal studies in both the agricultural sector and the laboratory indicate that artificial sweeteners may not only promote food intake and weight gain but can also induce metabolic alterations in a wide range of animal species. As a result, simple substitution of artificial sweeteners for sugars in humans may not produce the intended consequences. Instead consumption of artificial sweeteners might contribute to increases in risks for obesity or its attendant negative health outcomes. As a result, it is critical that the impacts of artificial sweeteners on health and disease continue to be more thoroughly evaluated in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.