Evidence map›Paper›PMID 27387309›Full record

ArticleJournal of racial and ethnic health disparities2017

Racial Differences in Bone Microarchitecture and Estimated Strength at the Distal Radius and Distal Tibia in Older Adolescent Girls: a Cross-Sectional Study.

Madhusmita Misra, Kathryn E Ackerman, Miriam A Bredella, Fatima Cody Stanford, Alexander T Faje, Alexandra Nordberg, Nicholas P Derrico, Mary L Bouxsein

Open access · greenAbstract read
In one paragraph

Article in Journal of racial and ethnic health disparities, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Biological Benchmarks for Adult Bone Mass Proportions in Young Females: A Prospective Longitudinal Analysis.American journal of human biology : the official journal of the Human Biology Council · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Racial and Ethnic Disparities in Bone Health and Outcomes in the United States.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Precision of bone density and micro-architectural properties at the distal radius and tibia in children: an HR-pQCT study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Madhusmita MisraNeuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, BUL 457, Boston, MA, 02114, USA. mmisra@mgh.harvard.edu.
Kathryn E AckermanNeuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, BUL 457, Boston, MA, 02114, USA.
Miriam A BredellaDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
Fatima Cody StanfordMGH Weight Center, Medicine-Gastrointestinal Unit, Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Alexander T FajeNeuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, BUL 457, Boston, MA, 02114, USA.
Alexandra NordbergNeuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, BUL 457, Boston, MA, 02114, USA.
Nicholas P DerricoEndocrine Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Mary L BouxseinEndocrine Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Harvard University · USMassachusetts General Hospital · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Effects of Anorexia Nervosa on Peak Bone MassR01DK062249 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KLIBANSKI, ANNE · 2003 to 2015
$7.2M
Fat Mediated Modulation of Reproductive and Endocrine Function in Young AthletesR01HD060827 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI MISRA, MADHUSMITA · 2009 to 2013
$2.4M
Bone Metabolism and Body Composition in Young AthletesK24HD071843 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI MISRA, MADHUSMITA · 2013 to 2017
$930k
X-Treme CT Equipment GrantS10RR023405 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI FINKELSTEIN, JOEL S · 2007 to 2007
$380k
NCRR NIH HHS S10 RR023405NCRR NIH HHS UL1 RR025758NICHD NIH HHS K24 HD071843NICHD NIH HHS R01 HD060827NIDDK NIH HHS R01 DK062249
6 · The paper itself

Abstract

backgroundPrevious studies have demonstrated that an individual's race and ethnicity are important determinants of their areal bone mineral density (aBMD), assessed by dual-energy X-ray absorptiometry. However, there are few data assessing the impact of race on bone microarchitecture and strength estimates, particularly in older adolescent girls and young adults. We hypothesized that bone microarchitecture and strength estimates would be superior in Blacks compared to White and Asian American adolescent girls and young adults of similar age based on reports of higher aBMD in Blacks.

methodsWe assessed BMD using dual-energy X-ray absoptiometry (DXA), bone microarchitecture at the distal radius and distal tibia using high-resolution peripheral quantitative computed tomography (HRpQCT) and estimated measures of bone strength using micro-finite element analysis (FEA) in 35 White, 15 Asian American, and 10 Black girls 14-21 years.

resultsAfter controlling for height, most DXA measures of aBMD and aBMD Z scores were higher in Black girls compared with Whites and Asian Americans. HRpQCT and FEA showed that at the distal radius, Blacks had greater cortical perimeter, cortical area, trabecular thickness, trabecular BMD, estimated failure load, and stiffness than the other two groups. For the distal tibia, trabecular number and BMD were higher in Blacks than Asian Americans.

conclusionsParticularly at the distal radius, adolescent and young adult White and Asian American girls have less favorable bone microarchitecture and lower bone strength than Blacks, possibly explaining the lower risk of fracture seen in Blacks. LEVEL OF EVIDENCE: Level II.

Indexed as

Bone DensityHealth Status DisparitiesAbsorptiometry, PhotonAdolescentAsianBlack or African AmericanCross-Sectional StudiesFemaleHumansRadiusTibiaWhite PeopleYoung AdultFailure loadFinite element analysisMicroarchitectureRace

Identifiers

PMID27387309
PMCPMC5222729
OpenAlexW2461023740

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.