ArticleScientific reports2016
Investigating the dynamics of surface-immobilized DNA nanomachines.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Electronic Actuation of Surface-Immobilized, pH-Responsive DNA Nanoswitches.ACS applied materials & interfaces · 2026Article
- Analyzing Binding Specificity in a Microparticle-Based DNA Displacement Assay Using Multiharmonic QCM-D.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Harnessing DNA Nanotechnology and Chemistry for Applications in Photonics and Electronics.Bioconjugate chemistry · 2023Review
- Controlling Dynamic DNA Reactions at the Surface of Single-Walled Carbon Nanotube Electrodes to Design Hybridization Platforms with a Specific Amperometric Readout.Analytical chemistry · 2022Article
- Article
- Rapid kinetic fingerprinting of single nucleic acid molecules by a FRET-based dynamic nanosensor.Biosensors & bioelectronics · 2021Article
- DNA-based communication in populations of synthetic protocells.Nature nanotechnology · 2019Article
- Tunable DNA Hybridization Enables Spatially and Temporally Controlled Surface-Anchoring of Biomolecular Cargo.Langmuir : the ACS journal of surfaces and colloids · 2018Article
- Towards a Bioelectronic Computer: A Theoretical Study of a Multi-Layer Biomolecular Computing System That Can Process Electronic Inputs.International journal of molecular sciences · 2018Article
- A spatially localized architecture for fast and modular DNA computing.Nature nanotechnology · 2017Article
- An experimental study of the putative mechanism of a synthetic autonomous rotary DNA nanomotor.Royal Society open science · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surface-immobilization of molecules can have a profound influence on their structure, function and dynamics. Toehold-mediated strand displacement is often used in solution to drive synthetic nanomachines made from DNA, but the effects of surface-immobilization on the mechanism and kinetics of this reaction have not yet been fully elucidated. Here we show that the kinetics of strand displacement in surface-immobilized nanomachines are significantly different to those of the solution phase reaction, and we attribute this to the effects of intermolecular interactions within the DNA layer. We demonstrate that the dynamics of strand displacement can be manipulated by changing strand length, concentration and G/C content. By inserting mismatched bases it is also possible to tune the rates of the constituent displacement processes (toehold-binding and branch migration) independently, and information can be encoded in the time-dependence of the overall reaction. Our findings will facilitate the rational design of surface-immobilized dynamic DNA nanomachines, including computing devices and track-based motors.
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