ArticleJournal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology2016
Failure of the first step of two-stage revision due to polymicrobial prosthetic joint infection of the hip.
Article in Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- [Antimicrobial therapy of periprosthetic joint infection : Full version of the AE guidelines (2026)].Orthopadie (Heidelberg, Germany) · 2026Review
- Systemic and local effects of vancomycin-combined thermal exposure on Staphylococcus aureus infected rat femurs: a comparative study of hyperthermia and thermal ablation.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- MRSA-dominant colonization and synergistic pathogenicity withJournal of orthopaedic translation · 2026Article
- What constitutes a true polymicrobial periprosthetic joint infection? From multiple detections to organism-level causality.Frontiers in microbiology · 2026Review
- Characterizing interactions of Staphylococcus aureus and Escherichia coli in dual-species implant-associated biofilms.NPJ biofilms and microbiomes · 2025Article
- One-year success after debridement, antibiotic therapy, and implant retention for acute hip and knee periprosthetic joint infection: a retrospective cohort study of 62 patients.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- Polymicrobial Prosthetic Joint Infections: Unraveling Risk Factors and Outcomes in a Single-Center Study.Microorganisms · 2025Article
- Article
- The Role of Applying Metagenomic Next-Generation Sequencing (mNGS) in Periprosthetic Joint Infection with Sinus Tract: A Retrospective Study.International journal of general medicine · 2025Article
- The presence of a sinus tract is associated with reinfection after two-stage revision surgery for prosthetic hip joint infection: a case-control study.BMC musculoskeletal disorders · 2024Article
- Effectiveness of two-stage revision with commercial polymethylmethacrylate articulated hip spacer: similar outcomes against monomicrobial and polymicrobial hip periprosthetic joint infections.Journal of bone and joint infection · 2023Article
- The reasons for and mortality of patients unable to receive reimplantation after resection arthroplasty for chronic hip periprosthetic infection.International orthopaedics · 2022Article
- Comparative analysis of pathogen structure in patients with PJI after primary total hip and knee arthroplasty.Archives of orthopaedic and trauma surgery · 2021Article
- The risk factors of polymicrobial periprosthetic joint infection: a single-center retrospective cohort study.BMC musculoskeletal disorders · 2021Article
- Is There a Difference in Microbiological Epidemiology and Effective Empiric Antimicrobial Therapy Comparing Fracture-Related Infection and Periprosthetic Joint Infection? A Retrospective Comparative Study.Antibiotics (Basel, Switzerland) · 2021Article
- Two-stage exchange Arthroplasty for knee Periprosthetic joint infection exhibit high infection recurrence rate in patients with chronic viral hepatitis.BMC musculoskeletal disorders · 2021Article
- Efficacy of 16S rRNA variable regions high-resolution melt analysis for bacterial pathogens identification in periprosthetic joint infections.BMC microbiology · 2021Article
- Microbial findings and the role of difficult-to-treat pathogens in patients with periprosthetic infection admitted to the intensive care unit.Orthopedic reviews · 2020Article
- Polymicrobial infections and microbial patterns in infected nonunions - a descriptive analysis of 42 cases.BMC infectious diseases · 2020Article
- Bacteria drug resistance profile affects knee and hip periprosthetic joint infection outcome with debridement, antibiotics and implant retention.BMC musculoskeletal disorders · 2020Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe unsuccessful treatment of prosthetic joint infection (PJI) with two-stage revision leads to infection recurrence. The objectives of the study were to assess the clinical and demographic characteristics of patients with polymicrobial PJI, and to evaluate the role of the microbial profile involved in PJI in the risk of infection recurrence after the first step of two-stage revision surgery. MATERIALS AND
methodsA retrospective analysis of 189 cases of culture-positive PJI following total hip replacement over a 5-year period was performed. The demographic characteristics of patients, clinical symptoms, microbiology cultures of intraoperative biopsies, laboratory values of C-reactive protein (CRP), white blood cell count and erythrocyte sedimentation rate were analyzed. Patients were divided into two groups-135 with monomicrobial and 54 with polymicrobial infection.
resultsOf all patients, 68.9 % in the monomicrobial and 83.3 % in the polymicrobial group had a body mass index >25 kg/m
conclusionsOverweight and obese patients or those with elevated CRP had a greater risk of polymicrobial PJI. They were predisposed to recurrence of infection after the first step of two-stage revision. An unsuccessful outcome was more likely in cases with polymicrobial infection compared to those with monomicrobial infection. In addition, the presence of multidrug-resistant strains of Gram-negative bacteria substantially increased the risk of PJI treatment being unsuccessful. LEVEL OF EVIDENCE: Level III, therapeutic study.
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