ArticleNature communications2016
A heavy metal P-type ATPase OsHMA4 prevents copper accumulation in rice grain.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed.
- Article
- A comparative approach for selecting orthologous candidate genes in genome-wide association studies across multiple species.Plant physiology · 2026Article
- A broad-spectrum inhibitor of copper-exporting PProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Applications of Gene-Editing Technologies in Enhancing Crop Stress Resistance with Emphasis on Rice.Plants (Basel, Switzerland) · 2026Review
- Functional characterization of transporter genes in rice node at single-cell resolution through multi-omics technologies.Genome biology · 2026Article
- A First-In-Class Broad Spectrum Inhibitor of Copper Exporting PbioRxiv : the preprint server for biology · 2026Article
- Functional annotation of novel heat stress-responsive genes in rice utilizing public transcriptomes and structurome.Bioinformatics advances · 2026Article
- Rapid acquisition of ionomic and morphological data from plant seeds through fast X-ray fluorescence microscopy and computer vision.Plant phenomics (Washington, D.C.) · 2025Article
- A Genome‑wide Association Study of the Grain Ionome in Rice Oryza Sativa Ssp. Japonica under Two Diverse Water Management Systems.Rice (New York, N.Y.) · 2025Article
- Molecular Evolution of Cu Transporters and Transcription Factors in Plant Response to Copper Stress.Plants (Basel, Switzerland) · 2025Review
- Rice Adaptation to Abiotic Stresses Caused by Soil Inorganic Elements.International journal of molecular sciences · 2025Review
- Prediction of new candidate proteins and analysis of sub-modules and protein hubs associated with seed development in rice (Oryza sativa) using an ensemble network-based systems biology approach.BMC plant biology · 2025Article
- Genome-Wide Association Studies Reveal the Genetic Architecture of Ionomic Variation in Grains of Tartary Buckwheat.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Bioinformatics and Functional Analysis of OsASMT1 Gene in Response to Abiotic Stress.Biochemical genetics · 2025Article
- QTL mapping and candidate gene analysis of element accumulation in rice grains via genome-wide association study and population genetic analysis.BMC plant biology · 2025Article
- Sensitivity of renal cell carcinoma to cuproptosis: a bioinformatics analysis and experimental verification.Journal of Cancer · 2025Article
- A chloroplast localized heavy metal-associated domain containing protein regulates grain calcium accumulation in rice.Nature communications · 2024Article
- Molecular Mechanisms of Plant Responses to Copper: From Deficiency to Excess.International journal of molecular sciences · 2024Review
- Genome-wide identification of heavy-metal ATPases genes in Areca catechu: investigating their functionality under heavy metal exposure.BMC plant biology · 2024Article
- Diverse roles of the metal binding domains and transport mechanism of copper transporting P-type ATPases.Nature communications · 2024Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Rice is a major source of calories and mineral nutrients for over half the world's human population. However, little is known in rice about the genetic basis of variation in accumulation of copper (Cu), an essential but potentially toxic nutrient. Here we identify OsHMA4 as the likely causal gene of a quantitative trait locus controlling Cu accumulation in rice grain. We provide evidence that OsHMA4 functions to sequester Cu into root vacuoles, limiting Cu accumulation in the grain. The difference in grain Cu accumulation is most likely attributed to a single amino acid substitution that leads to different OsHMA4 transport activity. The allele associated with low grain Cu was found in 67 of the 1,367 rice accessions investigated. Identification of natural allelic variation in OsHMA4 may facilitate the development of rice varieties with grain Cu concentrations tuned to both the concentration of Cu in the soil and dietary needs.
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