ArticleBMC cancer2016
Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer.
Article in BMC cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Relationship between NLR and penile squamous cell carcinoma: a systematic review and meta-analysis.BMC urology · 2024Pooled it
- Neutrophil-to-Lymphocyte Ratio Is a Potential Prognostic Biomarker in Patients with Ovarian Cancer: A Meta-Analysis.BioMed research international · 2017Pooled it
- Inflammation in Penile Squamous Cell Carcinoma: A Comprehensive Review.International journal of molecular sciences · 2025Review
- Real-World Outcomes in Patients with Advanced Penile Squamous Cell Carcinoma Receiving Immune Checkpoint Inhibitors: A Single Institution Experience.Journal of immunotherapy and precision oncology · 2025Article
- Neutrophil-to-lymphocyte ratio predicts a poor prognosis for penile cancer with an immunosuppressive tumor microenvironment.Frontiers in immunology · 2025Article
- Prognostic Significance of Systemic Inflammation Markers in Testicular and Penile Cancer: A Narrative Review of Current Literature.Life (Basel, Switzerland) · 2023Review
- Prognostic value of neutrophil-to-lymphocyte ratio (NLR) in penile cancer: A systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2022Review
- Preoperative risk stratification using plasma fibrinogen levels can predict lymphovascular invasion and poor prognosis in patients with upper urinary tract urothelial carcinoma.Molecular and clinical oncology · 2021Article
- Postoperative C-reactive protein-to-albumin ratio predicts poor prognosis in patients with bladder cancer undergoing radial cystectomy.Molecular and clinical oncology · 2021Article
- Article
- Prognostic value of systemic inflammatory factors NLR, LMR, PLR and LDH in penile cancer.BMC urology · 2020Article
- Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Penile Squamous Cell Carcinoma Patients Undergoing Inguinal Lymph Node Dissection.European urology focus · 2019Article
- Chronic kidney disease and positive surgical margins as prognosticators for upper urinary tract urothelial carcinoma patients undergoing radical nephroureterectomy.Molecular and clinical oncology · 2019Article
- Predictors of inguinal lymph node metastasis in penile cancer patients: a meta-analysis of retrospective studies.Cancer management and research · 2019Article
- Prognostic factors in patients with penile cancer after surgical management.World journal of urology · 2018Article
- Neutrophil to lymphocyte ratio may be a helpful marker to evaluate disease activity in NMOSD.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
- Management of penile cancer in a Singapore tertiary hospital.Arab journal of urology · 2017Article
- High Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Mortality in Chronic Hemodialysis Patients.Mediators of inflammation · 2017Article
- Prognostic and Predictive Factors in Patients with Advanced Penile Cancer Receiving Salvage (2nd or Later Line) Systemic Treatment: A Retrospective, Multi-Center Study.Frontiers in pharmacology · 2016Article
- Article
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response, has been demonstrated to correlate with patient outcomes for various solid malignancies. We investigated the utility of the pretreatment NLR as a prognosticator in patients who presented with penile cancer.
methodsA total of 41 patients who underwent complete blood count with differential and subsequent radical penectomy from 1988 to 2014 were analyzed. We assessed the correlation between the NLR and the prognosis of penile cancer.
resultsThe median and mean (± SD) NLRs in 41 penile cancer patients were 3.42 and 5.03 ± 4.99, respectively. Based on the area under receiver operator characteristic curve, the cut-off value of NLR was determined to be 2.82. Patients with a high NLR (≥2.82) showed a significantly poorer cancer-specific survival (p = 0.023) than those with a low NLR.
conclusionsThe pretreatment NLR may function as a biomarker that precisely predicts the prognosis in patients with penile cancer.
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