ArticleScience advances2016
Ultrasensitive interferometric on-chip microscopy of transparent objects.
Article in Science advances, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 36 citations in OpenAlex.
- Multispectral Holographic Intensity and Phase Imaging of Semitransparent Ultrathin Films.ACS photonics · 2024Article
- Quantitative phase imaging by gradient retardance optical microscopy.Scientific reports · 2024Article
- A quantum-enhanced wide-field phase imager.Science advances · 2021Article
- Interference-contrast optical activity: a new technique for probing the chirality of anisotropic samples and more.Royal Society open science · 2020Article
- Optical Interrogation Techniques for Nanophotonic Biochemical Sensors.Sensors (Basel, Switzerland) · 2019Review
- Attosecond-resolution Hong-Ou-Mandel interferometry.Science advances · 2018Article
- Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager.Light, science & applications · 2018Article
- 3D imaging of optically cleared tissue using a simplified CLARITY method and on-chip microscopy.Science advances · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Light microscopes can detect objects through several physical processes, such as scattering, absorption, and reflection. In transparent objects, these mechanisms are often too weak, and interference effects are more suitable to observe the tiny refractive index variations that produce phase shifts. We propose an on-chip microscope design that exploits birefringence in an unconventional geometry. It makes use of two sheared and quasi-overlapped illuminating beams experiencing relative phase shifts when going through the object, and a complementary metal-oxide-semiconductor image sensor array to record the resulting interference pattern. Unlike conventional microscopes, the beams are unfocused, leading to a very large field of view (20 mm(2)) and detection volume (more than 0.5 cm(3)), at the expense of lateral resolution. The high axial sensitivity (<1 nm) achieved using a novel phase-shifting interferometric operation makes the proposed device ideal for examining transparent substrates and reading microarrays of biomarkers. This is demonstrated by detecting nanometer-thick surface modulations on glass and single and double protein layers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.