ArticleScience advances2016
Octopamine connects nutrient cues to lipid metabolism upon nutrient deprivation.
Article in Science advances, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- Hungry for Knowledge: Octopamine Signaling Regulates Hunger-Enhanced Olfactory Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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- Nuclear receptor-neurotransmitter coupling links behavior to metabolic state.bioRxiv : the preprint server for biology · 2025Article
- Sensory plasticity caused by up-down regulation encodes the information of short-term learning and memory.iScience · 2025Article
- Functional analysis of conserved C. elegans bHLH family members uncovers lifespan control by a peptidergic hub neuron.PLoS biology · 2025Article
- Identification of serum metabolites associated with polybrominated diphenyl ethers (PBDEs) exposure in papillary thyroid carcinoma: a case-control study.Environmental geochemistry and health · 2024Article
- Functional analysis of conservedbioRxiv : the preprint server for biology · 2024Article
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- Profile of Prof. Ke-Qin Zhang.Science China. Life sciences · 2023Article
- Review
- Maintenance of quiescent oocytes by noradrenergic signals.Nature communications · 2021Article
- Knockdown of a β-Adrenergic-Like Octopamine Receptor Affects Locomotion and Reproduction ofInternational journal of molecular sciences · 2021Article
- Transcriptional Response to a Dauer-Inducing Ascaroside Cocktail in Late L1 inmicroPublication biology · 2021Article
- Chemosensory signal transduction in Caenorhabditis elegans.Genetics · 2021Review
- A Mutation ofmicroPublication biology · 2021Article
- A Multicellular Network Mechanism for Temperature-Robust Food Sensing.Cell reports · 2020Article
- Tyramine Acts Downstream of Neuronal XBP-1s to Coordinate Inter-tissue UPRDevelopmental cell · 2020Article
- Starvation Responses Throughout theGenetics · 2020Review
- Metabolic Control over mTOR-Dependent Diapause-like State.Developmental cell · 2020Article
- The physiology of movement.Movement ecology · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Starvation is probably the most common stressful situation in nature. In vertebrates, elevation of the biogenic amine norepinephrine levels is common during starvation. However, the precise role of norepinephrine in nutrient deprivation remains largely unknown. We report that in the free-living nematode Caenorhabditis elegans, up-regulation of the biosynthesis of octopamine, the invertebrate counterpart of norepinephrine, serves as a mechanism to adapt to starvation. During nutrient deprivation, the nuclear receptor DAF-12, known to sense nutritional cues, up-regulates the expression of tbh-1 that encodes tyramine β-hydroxylase, a key enzyme for octopamine biosynthesis, in the RIC neurons. Octopamine induces the expression of the lipase gene lips-6 via its receptor SER-3 in the intestine. LIPS-6, in turn, elicits lipid mobilization. Our findings reveal that octopamine acts as an endocrine regulator linking nutrient cues to lipolysis to maintain energy homeostasis, and suggest that such a mechanism may be evolutionally conserved in diverse organisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.