Evidence map›Paper›PMID 27386490›Full record

ReviewAnnals of translational medicine2016

In vitro reactivity ("organ chamber") of guinea pig tracheal rings-methodology considerations.

Agnes Afrodite Sumarelli Albuquerque, Marco Túlio Menezes Carvalho, Patricia Martinez Evora, Tales Rubens de Nadai, Andrea Carla Celotto, Paulo Roberto Barbosa Evora

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Supplementation WithFrontiers in pharmacology · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Agnes Afrodite Sumarelli Albuquerque1 Department of Surgery and Anatomy, Ribeirão Preto School of Medicine, University of São Paulo, Avenida Bandeirantes 3900, 14048-900 Ribeirão Preto, SP, Brazil ; 2 Department of Animal Pathology, Veterinary School, São Paulo State University-UNESP, Campus of Jaboticabal, Brazil.
Marco Túlio Menezes Carvalho1 Department of Surgery and Anatomy, Ribeirão Preto School of Medicine, University of São Paulo, Avenida Bandeirantes 3900, 14048-900 Ribeirão Preto, SP, Brazil ; 2 Department of Animal Pathology, Veterinary School, São Paulo State University-UNESP, Campus of Jaboticabal, Brazil.
Patricia Martinez Evora1 Department of Surgery and Anatomy, Ribeirão Preto School of Medicine, University of São Paulo, Avenida Bandeirantes 3900, 14048-900 Ribeirão Preto, SP, Brazil ; 2 Department of Animal Pathology, Veterinary School, São Paulo State University-UNESP, Campus of Jaboticabal, Brazil.
Tales Rubens de Nadai1 Department of Surgery and Anatomy, Ribeirão Preto School of Medicine, University of São Paulo, Avenida Bandeirantes 3900, 14048-900 Ribeirão Preto, SP, Brazil ; 2 Department of Animal Pathology, Veterinary School, São Paulo State University-UNESP, Campus of Jaboticabal, Brazil.
Andrea Carla Celotto1 Department of Surgery and Anatomy, Ribeirão Preto School of Medicine, University of São Paulo, Avenida Bandeirantes 3900, 14048-900 Ribeirão Preto, SP, Brazil ; 2 Department of Animal Pathology, Veterinary School, São Paulo State University-UNESP, Campus of Jaboticabal, Brazil.
Paulo Roberto Barbosa Evora1 Department of Surgery and Anatomy, Ribeirão Preto School of Medicine, University of São Paulo, Avenida Bandeirantes 3900, 14048-900 Ribeirão Preto, SP, Brazil ; 2 Department of Animal Pathology, Veterinary School, São Paulo State University-UNESP, Campus of Jaboticabal, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present text was motivated by the difficulties faced by our postgraduate students when using airways studies protocols and will take into consideration the three mechanisms of relaxation: (I) guanosine 3,5-cyclic monophosphate (cGMP)/NO-dependent; (II) adenosine 3,5-cyclic monophosphate (cAMP)/PGI2-dependent, and (III) hyperpolarization-dependent. Tracheal rings are studied in an organ bath containing a gassed physiological salt solution, usually at a temperature of 37 °C. An agent or procedure that causes contraction [acetylcholine (Ach) or metacholine] of the smooth muscle is needed before study airway dilator drugs. The presented airways studies protocols are useful to study the bronchial epithelial-dependent reactivity.

Indexed as

airway epitheliumguinea pigorgan-chambersTracheatracheal in vitro reactivity

Identifiers

PMID27386490
PMCPMC4916363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.