ArticleAnnals of translational medicine2016
Plasma alkaline phosphatase and survival in diabetic patients with acute myocardial infarction.
Article in Annals of translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Serum alkaline phosphatase levels and the risk of new-onset diabetes in hypertensive adults.Cardiovascular diabetology · 2020Trial
- From deep learning discovery to clinical validation: a new composite marker predicts mortality in type 2 diabetes.Cardiovascular diabetology. Endocrinology reports · 2025Article
- Alkaline Phosphatase to Albumin Ratio as a Novel Predictor of All-Cause Mortality in Critically Ill Patients With Atrial Fibrillation.Cardiology research and practice · 2025Article
- Levels of Blood Biomarkers among Patients with Myocardial Infarction in Comparison to Control Group.Ethiopian journal of health sciences · 2020Article
- Article
- Determination of alkaline phosphatase activity based on enzyme-triggered generation of a thiol and the fluorescence quenching of silver nanoclusters.Mikrochimica acta · 2019Article
- Antidiabetic therapy at admission and survival in diabetic patients with acute myocardial infarction.Porto biomedical journalArticle
- PR interval and survival in diabetic patients with acute myocardial infarction.Indian heart journalArticle
- Plasma alkaline phosphatase is associated with mortality risk in patients with aortic valve stenosis.Porto biomedical journalArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlkaline phosphatase (ALP) removes phosphate groups from many types of molecules. The aim of the present research was to study the relation between plasma ALP and survival in diabetic patients with myocardial infarction.
methodsRetrospective study: from 954 admissions (15 months period) in a coronary care unit, we selected 200 admissions corresponding to 195 patients with myocardial infarction and diabetes mellitus. Survival after no less than 48 months, and up to 61 months, after the myocardial infarction episode, was under study, in association with ALP levels.
resultsA relatively weak but significant correlation was seen between the peak plasma cardiac troponin I and ALP levels (r: 0.21, significance level: 0.003). Using the median value for ALP as cut-off (74 IU/L), plasma creatinine was significantly higher in patients with higher values for ALP. Patients with elevated ALP had decreased survival in Kaplan-Meier analysis (significance level in log-rank test: 0.032). This finding was noted for male patients (significance level in log-rank test: 0.035), but not for female patients (significance level in log-rank test: 0.497).
conclusionsElevated ALP acts as a prognostic indicator of decreased survival in diabetic patients with acute myocardial infarction, possibly in association to decreased renal function. This finding is limited to male patients, pointing to a possible different role for phosphatase activity in cardiovascular disease in male and female diabetic patients.
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