ArticleSpringerPlus2016
Natural deep eutectic solvents: cytotoxic profile.
Article in SpringerPlus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 277 citations in OpenAlex.
- Beyond Composition: Structure-Activity Relationships in Bioactive Deep Eutectic Systems.Pharmaceutics · 2026Review
- Sustainable valorization of grape pomace peels using NADES: a focus on selective recovery of anthocyanins and flavonols and bioactivity.Analytical and bioanalytical chemistry · 2026Article
- Deep eutectic solvents as an emerging platform for microbial carotenoids extraction: State of the art, prospects, and challenges.Food chemistry: X · 2026Review
- Current Status and Future Perspectives of Betaine and Betaine-Based Natural Deep Eutectic Solvents: A Review.Foods (Basel, Switzerland) · 2025Review
- The Versatility of NADES Across Applications.Molecules (Basel, Switzerland) · 2025Review
- Exploitation of ApulianMolecules (Basel, Switzerland) · 2025Article
- Natural deep eutectic solvents (NaDES): green solvents for pharmaceutical applications and beyond.Green chemistry : an international journal and green chemistry resource : GC · 2025Review
- Terpene-Based Eutectic Solvent Microdroplets: A Strategy to Combat Antibiotic-ResistantLangmuir : the ACS journal of surfaces and colloids · 2025Article
- Sustainable Extraction of Prospective Cosmetic Ingredients from Colombian Marine Macroalgae Using Natural Deep Eutectic Solvents.Marine drugs · 2025Article
- Ultrasonic-assisted extraction (UAE) of Javanese turmeric rhizomes using natural deep eutectic solvents (NADES): Screening, optimization, and in vitro cytotoxicity evaluation.Ultrasonics sonochemistry · 2025Article
- An Overview on the Role of Ionic Liquids and Deep Eutectic Solvents in Oral Pharmaceuticals.Pharmaceutics · 2025Review
- Article
- From Nature to Innovation: The Uncharted Potential of Natural Deep Eutectic Solvents.Molecules (Basel, Switzerland) · 2023Review
- The increasing importance of novel deep eutectic solvents as potential effective antimicrobials and other medicinal properties.World journal of microbiology & biotechnology · 2023Review
- Molecular Guide for Selecting Green Deep Eutectic Solvents with High Monosaccharide Solubility for Food Applications.ACS omega · 2023Article
- Characterization of eutectic mixtures of sugars and sugar-alcohols for cryopreservation.Journal of molecular liquids · 2023Article
- Article
- Controversy on the toxic nature of deep eutectic solvents and their potential contribution to environmental pollution.Heliyon · 2022Review
- The Greening of Anthocyanins: Eco-Friendly Techniques for Their Recovery from Agri-Food By-Products.Antioxidants (Basel, Switzerland) · 2022Review
- Fermented Ginger Extract in Natural Deep Eutectic Solvent Enhances Cytotoxicity by Inhibiting NF-κB Mediated CXC Chemokine Receptor 4 Expression in Oxaliplatin-Resistant Human Colorectal Cancer Cells.Antioxidants (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to investigate the cytotoxic profiles of different ternary natural deep eutectic solvents (NADESs) containing water. For this purpose, five different NADESs were prepared using choline chloride as a salt, alongside five hydrogen bond donors (HBD) namely glucose, fructose, sucrose, glycerol, and malonic acid. Water was added as a tertiary component during the eutectics preparation, except for the malonic acid-based mixture. Coincidentally, the latter was found to be more toxic than any of the water-based NADESs. A trend was observed between the cellular requirements of cancer cells, the viscosity of the NADESs, and their cytotoxicity. This study also highlights the first time application of the conductor-like screening model for real solvent (COSMO-RS) software for the analysis of the cytotoxic mechanism of NADESs. COSMO-RS simulation of the interactions between NADESs and cellular membranes' phospholipids suggested that NADESs strongly interacted with cell surfaces and that their accumulation and aggregation possibly defined their cytotoxicity. This reinforced the idea that careful selection of NADESs components is necessary, as it becomes evident that organic acids as HBD highly contribute to the increasing toxicity of these neoteric mixtures. Nevertheless, NADESs in general seem to possess relatively less acute toxicity profiles than their DESs parents. This opens the door for future large scale utilization of these mixtures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.