Evidence map›Paper›PMID 27386246›Full record

ArticleSpringerPlus2016

Porphyromonas gingivalis-induced miR-132 regulates TNFα expression in THP-1 derived macrophages.

Mi Hee Park, Eunjoo Park, Hyung-Joon Kim, Hee Sam Na, Jin Chung

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in SpringerPlus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mi Hee Park *Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan-si, Gyeongsangnam-do 626-870 South Korea.
Eunjoo Park *Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan-si, Gyeongsangnam-do 626-870 South Korea.
Hyung-Joon KimDepartment of Oral Physiology, School of Dentistry, Pusan National University, Yangsan-si, 626-870 South Korea.
Hee Sam NaDepartment of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan-si, Gyeongsangnam-do 626-870 South Korea.
Jin ChungDepartment of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan-si, Gyeongsangnam-do 626-870 South Korea.
Pusan National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeriodontitis is a chronic inflammatory disease induced by periodontopathogens such as Porphyromonas gingivalis (P. gingivalis). MicroRNAs (miRNAs) are small single-stranded noncoding RNAs that regulate gene expression at the level of translation. MiRNAs have been reported to be involved in inflammatory processes. In this study, we examined the effects of P. gingivalis-induced inflammatory miRNAs expression on TNFα production in THP-1 derived macrophages.

resultsPorphyromonas gingivalis induced the expression of miR-132. P. gingivalis-induced miR-132 expression was significantly inhibited by TLR2/4 knock-down and NF-κB inhibitor. Additionally, miR-132 antagomir strongly repressed production of TNFα. The expression of NFE2L2 and NFAT5, the putative target genes of miR-132 involved in regulation of TNFα, decreased in response to P. gingivalis. Furthermore, miR-132 antagomir rescued P. gingivalis-induced suppression of NFE2L2 and NFAT5.

conclusionsThese results suggest that the induction of miR-132 by P. gingivalis can modulate the pathogenesis of periodontitis induced via regulatory expression of TNFα.

Indexed as

InflammationmiR-132Porphyromonas gingivalisTNFα

Identifiers

PMID27386246
PMCPMC4912528
OpenAlexW2430206300

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.