ArticleAdipocyte
Surgical injury induces local and distant adipose tissue browning.
Article in Adipocyte. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Short-Term Endogenous Hydrogen Sulfide Upregulation
Dietary Restriction in Vascular Surgery
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Enhancing fat graft retention through adipose tissue browning: a systematic review.Stem cell research & therapy · 2025Pooled it
- Role of Perivascular Adipose Tissue in Vein Remodeling.Arteriosclerosis, thrombosis, and vascular biology · 2025Review
- Preoperative methionine restriction induces perivascular adipose tissue browning and improves vein graft remodeling in male mice.Nature communications · 2024Article
- Trauma-associated extracellular histones mediate inflammation via a MYD88-IRAK1-ERK signaling axis and induce lytic cell death in human adipocytes.Cell death & disease · 2024Article
- Adipose tissue: a neglected organ in the response to severe trauma?Cellular and molecular life sciences : CMLS · 2022Review
- Cardiac ischemia modulates white adipose tissue in a depot-specific manner.Frontiers in physiology · 2022Article
- The Effect of Fat Distribution on the Inflammatory Response of Multiple Trauma Patients-A Retrospective Study.Life (Basel, Switzerland) · 2021Article
- Review
- Topical Skin Treatment and Its Influence on Surgical Healing: Review of Literature and Underlying Physiology.Aesthetic surgery journal. Open forum · 2021Article
- The emerging roles of lactate as a redox substrate and signaling molecule in adipose tissues.Journal of physiology and biochemistry · 2020Review
- Beige Fat Maintenance; Toward a Sustained Metabolic Health.Frontiers in endocrinology · 2020Review
- Perivascular adipose tissue: epiphenomenon or local risk factor?International journal of obesity (2005) · 2017Review
- Role of adipose tissue in facial aging.Clinical interventions in aging · 2017Review
- Local perivascular adiponectin associates with lower extremity vascular operative wound complications.Surgery · 2016Article
- Novel Browning Agents, Mechanisms, and Therapeutic Potentials of Brown Adipose Tissue.BioMed research international · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adipose organ, which comprises brown, white and beige adipocytes, possesses remarkable plasticity in response to feeding and cold exposure. The development of beige adipocytes in white adipose tissue (WAT), a process called browning, represents a promising route to treat metabolic disorders. While surgical procedures constantly traumatize adipose tissue, its impact on adipocyte phenotype remains to be established. Herein, we studied the effect of trauma on adipocyte phenotype one day after sham, incision control, or surgical injury to the left inguinal adipose compartment. Caloric restriction was used to control for surgery-associated body temperature changes and weight loss. We characterized the trauma-induced cellular and molecular changes in subcutaneous, visceral, interscapular, and perivascular adipose tissue using histology, immunohistochemistry, gene expression, and flow cytometry analysis. After one day, surgical trauma stimulated adipose tissue browning at the site of injury and, importantly, in the contralateral inguinal depot. Browning was not present after incision only, and was largely independent of surgery-associated body temperature and weight loss. Adipose trauma rapidly recruited monocytes to the injured site and promoted alternatively activated macrophages. Conversely, PDGF receptor-positive beige progenitors were reduced. In this study, we identify adipose trauma as an unexpected driver of selected local and remote adipose tissue browning, holding important implications for the biologic response to surgical injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.