Evidence map›Paper›PMID 27386121›Full record

ArticleClinical case reports2016

Case report: successful retreatment of hepatitis C genotype 1b infection with sofosbuvir + simeprevir in a patient with cirrhosis who had prior virologic relapse after treatment with daclatasvir and asunaprevir.

Rifaat Safadi, Stephanie Noviello, Navdeep Boparai, Fiona McPhee

Open access · goldAbstract readCase Reports
In one paragraph

Article in Clinical case reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Rifaat SafadiDivision of Medicine Institute of Gastroenterology and Liver Diseases Hadassah Medical Organization Hadassah Hebrew University Medical Center Jerusalem Israel; The Liver Unit Institute of Gastroenterology and Liver Diseases Division of Medicine Hadassah Medical Organization Hadassah Hebrew University Medical Center Jerusalem Israel.
Stephanie NovielloBristol-Myers Squibb Research and Development Princeton New Jersey.
Navdeep BoparaiBristol-Myers Squibb Research and Development Princeton New Jersey.
Fiona McPheeBristol-Myers Squibb Research and Development Wallingford Connecticut.
Bristol-Myers Squibb (United States) · USHadassah Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is currently minimal clinical experience regarding retreatment options for patients failing direct-acting antiviral combination regimens. Here, we report the outcomes of a HCV genotype 1b-infected patient with virologic failure following treatment with daclatasvir and asunaprevir, who was successfully retreated with sofosbuvir plus simeprevir.

Indexed as

AsunaprevirdaclatasvirHCVretreatment

Identifiers

PMID27386121
PMCPMC4929798
OpenAlexW2467088020

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.