ArticleThe Plant cell2016
The PHD Finger Protein MMD1/DUET Ensures the Progression of Male Meiotic Chromosome Condensation and Directly Regulates the Expression of the Condensin Gene CAP-D3.
Article in The Plant cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Heterochromatin in plant meiosis.Nucleus (Austin, Tex.) · 2024Review
- Genome-Wide Identification and Expression Analysis of the PHD Finger Gene Family in Pea (Plants (Basel, Switzerland) · 2024Article
- Regulation of micro- and small-exon retention and other splicing processes by GRP20 for flower development.Nature plants · 2024Article
- Article
- The genetic architecture of prolificacy in maize revealed by association mapping and bulk segregant analysis.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Functional importance and divergence of plant apurinic/apyrimidinic endonucleases in somatic and meiotic DNA repair.The Plant cell · 2023Article
- The scaffold nucleoporins SAR1 and SAR3 are essential for proper meiotic progression inFrontiers in cell and developmental biology · 2023Article
- PHD finger proteins function in plant development and abiotic stress responses: an overview.Frontiers in plant science · 2023Review
- MS1/MMD1 homologues in the moss Physcomitrium patens are required for male and female gametogenesis.The New phytologist · 2022Article
- Review
- Article
- Comparison of Metabolic Profiling ofPhenomics (Cham, Switzerland) · 2021Article
- Cell-type-dependent histone demethylase specificity promotes meiotic chromosome condensation in Arabidopsis.Nature plants · 2020Article
- The cohesin loader SCC2 contains a PHD finger that is required for meiosis in land plants.PLoS genetics · 2020Article
- ATM Promotes RAD51-Mediated Meiotic DSB Repair by Inter-Sister-Chromatid Recombination inFrontiers in plant science · 2020Article
- Comparative transcript profiling and cytological observation of the newly bred recessive genic male sterility non-heading Chinese cabbage (Brassica rapa ssp. chinensis) line WS24-3A.Genes & genomics · 2019Article
- The Arabidopsis anaphase-promoting complex/cyclosome subunit 8 is required for male meiosis.The New phytologist · 2019Article
- TDR INTERACTING PROTEIN 3, encoding a PHD-finger transcription factor, regulates Ubisch bodies and pollen wall formation in rice.The Plant journal : for cell and molecular biology · 2019Article
- Mutation in a PHD-finger protein MS4 causes male sterility in soybean.BMC plant biology · 2019Article
- Tapetum-Dependent Male Meiosis Progression in Plants: Increasing Evidence Emerges.Frontiers in plant science · 2019Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromosome condensation, a process mediated by the condensin complex, is essential for proper chromosome segregation during cell division. Unlike rapid mitotic chromosome condensation, meiotic chromosome condensation occurs over a relatively long prophase I and is unusually complex due to the coordination with chromosome axis formation and homolog interaction. The molecular mechanisms that regulate meiotic chromosome condensation progression from prophase I to metaphase I are unclear. Here, we show that the Arabidopsis thaliana meiotic PHD-finger protein MMD1/DUET is required for progressive compaction of prophase I chromosomes to metaphase I bivalents. The MMD1 PHD domain is required for its function in chromosome condensation and binds to methylated histone tails. Transcriptome analysis and qRT-PCR showed that several condensin genes exhibit significantly reduced expression in mmd1 meiocytes. Furthermore, MMD1 specifically binds to the promoter region of the condensin subunit gene CAP-D3 to enhance its expression. Moreover, cap-d3 mutants exhibit similar chromosome condensation defects, revealing an MMD1-dependent mechanism for regulating meiotic chromosome condensation, which functions in part by promoting condensin gene expression. Together, these discoveries provide strong evidence that the histone reader MMD1/DUET defines an important step for regulating the progression of meiotic prophase I chromosome condensation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.