ArticleThe Journal of bone and joint surgery. American volume2016
Bone Morphogenetic Protein Use and Cancer Risk Among Patients Undergoing Lumbar Arthrodesis: A Case-Cohort Study Using the SEER-Medicare Database.
Article in The Journal of bone and joint surgery. American volume, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 37 citations in OpenAlex.
- Temporal Trends and Projected Burden of Bone and Articular Cartilage Malignancies in East Asia: A Systematic Analysis for the Global Burden of Disease Study 2023.Orthopedic research and reviews · 2026Article
- Orthobiologics in spine surgery: a narrative review.Journal of spine surgery (Hong Kong) · 2025Review
- Usage Trends and Safety Profile of Recombinant Human Bone Morphogenetic Protein-2 for Spinal Column Tumor Surgery: A National Matched Cohort Analysis.Global spine journal · 2025Article
- Management of non-unions of the malleolar fractures- Current Evidence.Journal of clinical orthopaedics and trauma · 2024Article
- Bioactive Bone Substitute in a Rabbit Ulna Model: Preclinical Study.Tissue engineering and regenerative medicine · 2023Article
- Current Status of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) in Maxillofacial Surgery: Should It Be Continued?Bioengineering (Basel, Switzerland) · 2023Review
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- Can Adding BMP2 Improve Outcomes in Patients Undergoing the SUPERhip Procedure?Children (Basel, Switzerland) · 2021Article
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- Management of Pseudarthrosis With Implant Failure at a Multilevel Vertebral Column Resection Site: A Case Report.Neurospine · 2020Article
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- Biocompatible PLGA-Mesoporous Silicon Microspheres for the Controlled Release of BMP-2 for Bone Augmentation.Pharmaceutics · 2020Article
- Harvest of Iliac Crest Autograft Not Associated With Localized Pain.International journal of spine surgery · 2019Article
- Risk of Cancer Following Lumbar Fusion Surgery With Recombinant Human Bone Morphogenic Protein-2 (rhBMP-2): An Analysis Using a Commercially Insured Patient Population.International journal of spine surgery · 2018Article
- 3D anatomical and perfusion MRI for longitudinal evaluation of biomaterials for bone regeneration of femoral bone defect in rats.Scientific reports · 2017Article
- Use of recombinant human bone morphogenetic protein-2 in spine surgery.World journal of orthopedics · 2017Review
- Comparison of a calcium phosphate bone substitute with recombinant human bone morphogenetic protein-2: a prospective study of fusion rates, clinical outcomes and complications with 24-month follow-up.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2017Article
- Strontium-doped hydroxyapatite polysaccharide materials effect on ectopic bone formation.PloS one · 2017Article
- The biology of bone lengthening.Journal of children's orthopaedics · 2016Review
- A Systematic Review of the Systematic Utilitarian Procedure for Extremity Reconstruction of the Hip (SUPERhip) for Congenital Femoral Deficiency with Reference to Recent Extra-network Cohort Findings.Strategies in trauma and limb reconstructionReview
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecombinant bone morphogenetic proteins (BMPs) are growth factors utilized in lumbar arthrodeses. Limited data from randomized trials suggest that BMP may increase cancer risk. We sought to evaluate cancer risk and mortality following the use of BMP in lumbar arthrodesis.
methodsWithin the linked Surveillance, Epidemiology, and End Results (SEER) Program-Medicare cohort, we conducted a case-cohort study of 7,278 individuals who were ≥65 years of age and had undergone a lumbar arthrodesis from 2004 to 2011. Of these patients, 3,627 were individuals in a 5% random subcohort of Medicare enrollees in SEER areas including 191 who developed cancer, and there were 3,651 individuals outside the subcohort who developed cancer. Weighted Cox proportional-hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for cancer on the basis of exposure to BMP.
resultsIn the SEER-Medicare subcohort, 30.7% of individuals who underwent a lumbar arthrodesis received BMP. BMP was not associated with overall cancer risk in univariate analyses (HR, 0.92 [95% CI, 0.82 to 1.02]) or after adjustment for demographic characteristics, comorbidities, hospital size, history of cancer, and calendar year (adjusted HR, 0.94 [95% CI, 0.84 to 1.05]). Individual cancer types were also not significantly elevated (p > 0.05 for all) in BMP users compared with nonusers. In addition, BMP use was not associated with a new cancer in people who had cancer prior to undergoing lumbar arthrodesis (adjusted HR, 1.04 [95% CI, 0.71 to 1.52]) or with mortality after a cancer diagnosis (adjusted HR, 1.05 [95% CI, 0.93 to 1.19]).
conclusionsIn a large population of elderly U.S. adults undergoing lumbar arthrodesis, BMP use was not associated with cancer risk or mortality. LEVEL OF EVIDENCE: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
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