ArticleThe American journal of clinical nutrition2016
The vitamin D status of the US population from 1988 to 2010 using standardized serum concentrations of 25-hydroxyvitamin D shows recent modest increases.
Article in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03320109 (Vitamin D Status and Intakes and Their Association With Cognitive Trajectory in a Longitudinal Study of Urban Adults), which is not on this map. Cited by 106 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vitamin D Status and Intakes and Their Association With Cognitive Trajectory in a Longitudinal Study of Urban Adults
Who cites it
106 citing papers in PubMed, 2 syntheses or guidelines pooled it, 195 citations in OpenAlex.
- Pooled it
- Vitamin D levels and deficiency with different occupations: a systematic review.BMC public health · 2017Pooled it
- Association of standardized serum 25-hydroxyvitamin D with falls in post-menopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Trial
- Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes.The Journal of clinical endocrinology and metabolism · 2022Trial
- Trial
- Effect of Higher vs Standard Dosage of Vitamin D3 Supplementation on Bone Strength and Infection in Healthy Infants: A Randomized Clinical Trial.JAMA pediatrics · 2018Trial
- Association between serum 25-hydroxyvitamin D and osteoarthritis prevalence in US adults: a cross-sectional study using NHANES 2007-2023.Annals of medicine and surgery (2012) · 2026Article
- Vitamin D deficiency among Ethiopian adults: current evidence, determinants, and policy implications.Annals of medicine and surgery (2012) · 2026Review
- Update on Vitamin D Status and Seasonal Variation in a Non-Supplemented Population Living in a High Polluted Urban Area-A Cross-Sectional Study.Nutrients · 2026Article
- Association between serum 25-hydroxyvitamin D concentrations and overactive bladder in female: a mediation analysis of inflammatory biomarkers.Frontiers in nutrition · 2026Article
- Exploring Vitamin D Trends Through Big Data Analysis.Nutrients · 2025Article
- Article
- Commutability assessment of new standard reference materials (SRMs) for determining serum total 25-hydroxyvitamin D using ligand binding and liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays.Analytical and bioanalytical chemistry · 2025Article
- Secular trends of vitamin D and calcium intake and their circulating levels in US adults from 2007 to 2018.Frontiers in nutrition · 2025Article
- Sunscreen use associated with elevated prevalence of anti-nuclear antibodies in U.S. adults.Journal of autoimmunity · 2024Article
- Prevalence and risk factors of vitamin D deficiency among Afghan primary school children.Scientific reports · 2024Article
- Article
- Prevalence of low vitamin D status in an urban district in Sri Lanka: a population-based study.BMC nutrition · 2024Article
- Article
- Association between serum 25-hydroxyvitamin D and antimüllerian hormone levels in a cohort of African-American women.Fertility and sterility · 2024Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTemporal trends in the US population's vitamin D status have been uncertain because of nonstandardized serum 25-hydroxyvitamin D [25(OH)D] measurements.
objectiveTo accurately assess vitamin D status trends among those aged ≥12 y, we used data from the cross-sectional NHANESs.
designA liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for measuring 25(OH)D (sum of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3), calibrated to standard reference materials, was used to predict LC-MS/MS-equivalent concentrations from radioimmunoassay data (1988-2006 surveys; n = 38,700) and to measure LC-MS/MS concentrations (2007-2010 surveys; n = 12,446). Weighted arithmetic means and the prevalence of 25(OH)D above or below cutoff concentrations were calculated to evaluate long-term trends.
resultsOverall, mean predicted 25(OH)D showed no time trend from 1988 to 2006, but during 2007-2010 the mean measured 25(OH)D was 5-6 nmol/L higher. Those groups who showed the largest 25(OH)D increases (7-11 nmol/L) were older, female, non-Hispanic white, and vitamin D supplement users. During 1988-2010, the proportions of persons with 25(OH)D <40 nmol/L were 14-18% (overall), 46-60% (non-Hispanic blacks), 21-28% (Mexican Americans), and 6-10% (non-Hispanic whites).
conclusionsAn accurate method for measuring 25(OH)D showed stable mean concentrations in the US population (1988-2006) and recent modest increases (2007-2010). Although it is unclear to what extent supplement usage compared with different laboratory methods explain the increases in 25(OH)D, the use of higher vitamin D supplement dosages coincided with the increase. Marked race-ethnic differences in 25(OH)D concentrations were apparent. These data provide the first standardized information about temporal trends in the vitamin D status of the US population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.