Evidence map›Paper›PMID 27385511›Full record

ArticleHIV medicine2017

Age, time living with diagnosed HIV infection, and self-rated health.

J A McGowan, L Sherr, A J Rodger, M Fisher, A Miners, J Anderson, M A Johnson, J Elford, S Collins, G Hart and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HIV medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

J A McGowanResearch Department of Infection and Population Health, University College London, London, UK.
L SherrResearch Department of Infection and Population Health, University College London, London, UK.
A J RodgerResearch Department of Infection and Population Health, University College London, London, UK.
M FisherBrighton and Sussex University Hospitals NHS Trust, Brighton, UK.
A MinersLondon School of Hygiene and Tropical Medicine, London, UK.
J AndersonHomerton University Hospital NHS Foundation Trust, London, UK.
M A JohnsonRoyal Free London NHS Foundation Trust, London, UK.
J ElfordSchool of Health Sciences, City University, London, UK.
S CollinsHIV i-Base, London, UK.
G HartResearch Department of Infection and Population Health, University College London, London, UK.
A N PhillipsResearch Department of Infection and Population Health, University College London, London, UK.
A SpeakmanResearch Department of Infection and Population Health, University College London, London, UK.
F C LampeResearch Department of Infection and Population Health, University College London, London, UK.
Antiretrovirals, Sexual Transmission Risk and Attitudes (ASTRA) Study Group
University College London · GBCity, University of London · GBHomerton University Hospital NHS Foundation Trust · GBLondon School of Hygiene & Tropical Medicine · GBRoyal Free London NHS Foundation Trust · GBUniversity Hospitals Sussex NHS Foundation Trust · GB

Funding

Department of Health RP-PG-0608-10142
6 · The paper itself

Abstract

objectivesAn increasing proportion of people living with HIV are older adults, who may require specialized care. Adverse physical and psychological effects of HIV infection may be greatest among older people or those who have lived longer with HIV.

methodsThe ASTRA study is a cross-sectional questionnaire study of 3258 HIV-diagnosed adults (2248 men who have sex with men, 373 heterosexual men and 637 women) recruited from UK clinics in 2011-2012. Associations of age group with physical symptom distress (significant distress for at least one of 26 symptoms), depression and anxiety symptoms (scores ≥ 10 on PHQ-9 and GAD-7, respectively), and health-related functional problems (problems on at least one of three domains of the Euroqol 5D-3L)) were assessed, adjusting for time with diagnosed HIV infection, gender/sexual orientation and ethnicity.

resultsThe age distribution of participants was: < 30 years, 5%; 30-39 years, 23%; 40-49 years, 43%; 50-59 years, 22%; and ≥ 60 years, 7%. Overall prevalences were: physical symptom distress, 56%; depression symptoms, 27%; anxiety symptoms, 22%; functional problems, 38%. No trend was found in the prevalence of physical symptom distress with age [adjusted odds ratio (OR) for trend across age groups, 0.96; 95% confidence interval (CI) 0.89, 1.04; P = 0.36]. The prevalence of depression and anxiety symptoms decreased with age [adjusted OR 0.86 (95% CI 0.79, 0.94; P = 0.001) and adjusted OR 0.85 (95% CI 0.77, 0.94; P = 0.001), respectively], while that of functional problems increased (adjusted OR 1.28; 95% CI 1.17, 1.39; P < 0.001). In contrast, a longer time with diagnosed HIV infection was strongly and independently associated with a higher prevalence of symptom distress, depression symptoms, anxiety symptoms, and functional problems (P < 0.001 for trends, adjusted analysis).

conclusionsAmong people living with HIV, although health-related functional problems were more common with older age, physical symptom distress was not, and mental health was more favourable. These results suggest that a longer time with diagnosed HIV infection, rather than age, is the dominating factor contributing to psychological morbidity and lower quality of life.

Indexed as

AdolescentAdultAgedAged, 80 and overAge FactorsAnxietyCross-Sectional StudiesDepressionFemaleHIV InfectionsHumansMaleMiddle AgedSurveys and QuestionnairesTime FactorsUnited KingdomageinganxietydepressionHIVsymptomswellbeing

Identifiers

PMID27385511
PMCPMC5245118
OpenAlexW2462004899

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.