ArticleScientific reports2016
An investigation of the antibacterial ability and cytotoxicity of a novel cu-bearing 317L stainless steel.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 56 citations in OpenAlex.
- Cytotoxicity and antibacterial activity of polyhedral oligomeric silsesquioxane modified TiScientific reports · 2025Article
- The impact of alloying element Cu on corrosion and biofilms of 316L stainless steel exposed to seawater.Environmental science and pollution research international · 2024Article
- Microbially Influenced Corrosion of Steel in Marine Environments: A Review from Mechanisms to Prevention.Microorganisms · 2023Review
- Anti-pathogen stainless steel combating COVID-19.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2022Article
- Application of Copper Nanoparticles in Dentistry.Nanomaterials (Basel, Switzerland) · 2022Review
- Plasma SiOx:H Nanocoatings to Enhance the Antibacterial and Anti-Inflammatory Properties of Biomaterials.International journal of nanomedicine · 2022Article
- Osteoblastic Cell Responses of Copper Nanoparticle Coatings on Ti-6Al-7Nb Alloy Using Electrophoretic Deposition Method.BioMed research international · 2022Article
- Antibacterial metals and alloys for potential biomedical implants.Bioactive materials · 2021Review
- Biological applications of copper-containing materials.Bioactive materials · 2021Review
- Copper-Containing Alloy as Immunoregulatory Material in Bone Regeneration via Mitochondrial Oxidative Stress.Frontiers in bioengineering and biotechnology · 2020Article
- Multifunctional Copper-Containing Mesoporous Glass Nanoparticles as Antibacterial and Proangiogenic Agents for Chronic Wounds.Frontiers in bioengineering and biotechnology · 2020Article
- The inhibitory mechanism of aurintricarboxylic acid targeting serine/threonine phosphatase Stp1 in Staphylococcus aureus: insights from molecular dynamics simulations.Acta pharmacologica Sinica · 2019Article
- An antibacterial and biocompatible piperazine polymer.RSC advances · 2019Article
- Characterisation of the Chemical Composition and Structural Features of Novel Antimicrobial Nanoparticles.Nanomaterials (Basel, Switzerland) · 2017Article
- Nano-copper-bearing stainless steel promotes fracture healing by accelerating the callus evolution process.International journal of nanomedicine · 2017Article
- Inhibition of Staphylococcus aureus biofilm by Lactobacillus isolated from fine cocoa.BMC microbiology · 2016Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to solve the challenging problem of microbial infections caused by microorganisms on medical implants, it is imperative to develop novel antimicrobial biomaterials. This work demonstrated that 317L-Cu stainless steel (SS), created by adding copper through a solution and aging heat treatment process, exhibited good antibacterial properties against staphylococcus aureus, achieving 2 log reduction of planktonic cells after 5 days of incubation. In this study, the antibacterial test was performed using the plate count method, the fluorescence cell staining method and the quantitative polymerase chain reaction (qPCR) method. It is well known that a high concentration of copper ion can lead to cytotoxicity. This work explored the cytotoxicity of 317L-Cu SS through real-time cell analysis (RTCA). Experimental results demonstrated that the 317L-Cu SS possessed a satisfactory antibacterial ability against S. aureus, and the antibacterial rate based on the reduction of sessile cell count reached 98.3% after 24-hour treatment. The bacterial adhesion and the biofilm thickness were considerably reduced by the 317L-Cu SS. The results of RTCA suggested that 317L-Cu SS did not introduce cytotoxicity to mouse cells, indicating its suitability as a medical implant material.
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