ArticleScientific reports2016
Citrate Accumulation-Related Gene Expression and/or Enzyme Activity Analysis Combined With Metabolomics Provide a Novel Insight for an Orange Mutant.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 84 citations in OpenAlex.
- Molecular orchestration of malate and citrate metabolism: regulatory networks governing organic acid dynamics and fruit quality attributes.Horticulture research · 2026Article
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- PbrNAC34a- PbrMYB3/65- PbrACO2 cascade plays a role in citrate difference between the pericarp and cortex tissues of pear (P. bretschneideri Rehd.) fruit.Molecular horticulture · 2025Article
- Study on the differences in sugar-acid metabolism of Sweet Orange 'Newhall' with different rootstocks.BMC plant biology · 2025Article
- Exogenous Application of Glycine Betaine toInternational journal of molecular sciences · 2025Article
- Multidimensional Transcriptomics Reveals the Key Genes and Pathways Regulating the Acidity of Apples.Current issues in molecular biology · 2025Article
- AP2 transcription factor CsAIL6 negatively regulates citric acid accumulation in citrus fruits by interacting with a WD40 protein CsAN11.Horticulture research · 2025Article
- The Therapeutic Potential of Orange Juice in Cardiac Remodeling: A Metabolomics Approach.Metabolites · 2025Article
- OsJAZ10 Modulates Metabolite Profiles in Rice Seedlings in Response to Alkaline Stress.Rice (New York, N.Y.) · 2025Article
- ATP Citrate LyasePlants (Basel, Switzerland) · 2024Article
- Vacuolar proteomic analysis reveals tonoplast transporters for accumulation of citric acid and sugar in citrus fruit.Horticulture research · 2024Article
- Analysis of sugar components and identification ofFrontiers in plant science · 2024Article
- Article
- GABA shunt pathway is stimulated in response to early defoliation-induced carbohydrate limitation in Mandarin fruits.Heliyon · 2023Article
- Comprehensive analyses of the citrus WRKY gene family involved in the metabolism of fruit sugars and organic acids.Frontiers in plant science · 2023Article
- Metabolomic and transcriptomic analyses reveal the effects of grafting on blood orange quality.Frontiers in plant science · 2023Article
- Effects of exogenous melatonin on sugar and organic acid metabolism in early-ripening peach fruits.PloS one · 2023Article
- Acetylome reprograming participates in the establishment of fruit metabolism during polyploidization in citrus.Plant physiology · 2022Article
- Fruit Characteristics of Citrus Trees Grown under Different Soil Cu Levels.Plants (Basel, Switzerland) · 2022Article
- Bioactive Compounds, Nutritional Quality and Antioxidant Capacity of the Red-Fleshed Kirkwood Navel and Ruby Valencia Oranges.Antioxidants (Basel, Switzerland) · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
'Hong Anliu' (HAL, Citrus sinensis cv. Hong Anliu) is a bud mutant of 'Anliu' (AL), characterized by a comprehensive metabolite alteration, such as lower accumulation of citrate, high accumulation of lycopene and soluble sugars in fruit juice sacs. Due to carboxylic acid metabolism connects other metabolite biosynthesis and/or catabolism networks, we therefore focused analyzing citrate accumulation-related gene expression profiles and/or enzyme activities, along with metabolic fingerprinting between 'HAL' and 'AL'. Compared with 'AL', the transcript levels of citrate biosynthesis- and utilization-related genes and/or the activities of their respective enzymes such as citrate synthase, cytosol aconitase and ATP-citrate lyase were significantly higher in 'HAL'. Nevertheless, the mitochondrial aconitase activity, the gene transcript levels of proton pumps, including vacuolar H(+)-ATPase, vacuolar H(+)-PPase, and the juice sac-predominant p-type proton pump gene (CsPH8) were significantly lower in 'HAL'. These results implied that 'HAL' has higher abilities for citrate biosynthesis and utilization, but lower ability for the citrate uptake into vacuole compared with 'AL'. Combined with the metabolites-analyzing results, a model was then established and suggested that the reduction in proton pump activity is the key factor for the low citrate accumulation and the comprehensive metabolite alterations as well in 'HAL'.
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