Evidence map›Paper›PMID 27385396›Full record

ArticleMolecular medicine (Cambridge, Mass.)2016

Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine.

Gyu Song, Eleonora Napoli, Sarah Wong, Randi Hagerman, Siming Liu, Flora Tassone, Cecilia Giulivi

Open access · goldAbstract read
In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 68 citations in OpenAlex.

  1. Trial
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  5. Chronic pain, fatigue, and emotional distress in femaleFrontiers in molecular neuroscience · 2026
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  12. The Role of NRF2 in Trinucleotide Repeat Expansion Disorders.Antioxidants (Basel, Switzerland) · 2024
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  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gyu SongDepartment of Molecular Biosciences, School of Veterinary Medicine, Davis, CA 95616.
Eleonora NapoliDepartment of Molecular Biosciences, School of Veterinary Medicine, Davis, CA 95616.
Sarah WongDepartment of Molecular Biosciences, School of Veterinary Medicine, Davis, CA 95616.
Randi HagermanMedical Investigations of Neurodevelopmental Disorders (MIND) Institute, University of California Davis, CA 95817.
Siming LiuDepartment of Molecular Biosciences, School of Veterinary Medicine, Davis, CA 95616.
Flora TassoneMedical Investigations of Neurodevelopmental Disorders (MIND) Institute, University of California Davis, CA 95817.
Cecilia GiuliviDepartment of Molecular Biosciences, School of Veterinary Medicine, Davis, CA 95616.
University of California, Davis · US

Funding

GENOTYPE/PHENOTYPE RELATIONSHIPS IN FRAGILE X FAMILIESR01HD036071 · NICHD · UNIVERSITY OF CALIFORNIA DAVIS · PI PAUL J HAGERMAN, RANDI J. HAGERMAN · 1998 to 2026
$13.8M
Rodent Behavior CoreU54HD079125 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ABBEDUTO, LEONARD J. · 2013 to 2019
$8.5M
Expression of the Fragile X GeneR01HD040661 · NICHD · UNIVERSITY OF CALIFORNIA DAVIS · PI HAGERMAN, PAUL J · 2002 to 2016
$4.3M
POPULATION-BASED BIRTH DEFECTS SURVEILLANCE AND UTILAZATION OF SURVEILLANCE DATA U50DD000596 · DD · COLORADO STATE DEPT/PUB HLTH & ENVIRONMT · PI RUTTENBER, MARGARET · 2010 to 2015
$1.1M
Electron Paramagnetic Resonance SpectrometerS10RR023586 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GIULIVI, CECILIA · 2009 to 2009
$475k
Antioxidants and oxidative damage in mitochondriaR01ES012691 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI GIULIVI, CECILIA · 2004 to 2004
$148k
NCBDD CDC HHS U50 DD000596NCRR NIH HHS S10 RR023586NICHD NIH HHS R01 HD036071NICHD NIH HHS R01 HD040661NICHD NIH HHS U54 HD079125NIEHS NIH HHS R01 ES012691
6 · The paper itself

Abstract

A 55-200 expansion of the CGG nucleotide repeat in the 5'-UTR of the fragile X mental retardation 1 gene (

Indexed as

antioxidantsfree radicalsmetabolismmitochondrianeurobiologyneurodegenerationeurodegenerationNeurodegenerative disordersoxidative stresspersonalized medicinereactive oxygen speciestriplet nucleotide disease

Identifiers

PMID27385396
PMCPMC5082295
OpenAlexW2491223703

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.